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31 results found


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Medtronic Harmony TPV Post-Approval Study

The purpose of this study is to evaluate the functionality of transcatheter implantation (a minimally invasive procedure) of the Medtronic Harmony Transcatheter Pulmonary Valve (TPV). Significant pulmonary regurgitation (abnormal reversal of blood flow in the ...


Lung

Open vs. Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

The purpose of this study is to compare the effects of 2 surgery methods for people with bone cancer (osteosarcoma- OST) that has spread to the lung. The 2 types of surgeries are called open ...


Brain and Nervous System

Chemotherapy Followed By WVSCI For Non-Germinomatous Central Nervous System Germ Cell Tumor

This study focuses on individuals who have been diagnosed with a type of brain cancer called non-germinomatous germ cell tumor (NGGCT) and whose tumor is “localized” (has not spread to other parts of the brain ...


Other

Outcomes of Children Newly Diagnosed with Crohn’s Disease

The purpose of this study is to determine the reasons why some children with newly diagnosed Crohn’s disease (CD) heal their bowel inflammation after one type of therapy and why others do not. CD is ...


Kidney

COG, AREN1921, Ph2, Open-label, DAWT + FHWT, chemotherapy

Primary Aims 1.1.1 To evaluate whether the addition of vincristine/irinotecan to cyclophosphamide/ carboplatin/etoposide alternating with vincristine/doxorubicin/cyclophosphamide improves the event-free survival (EFS) of patients with newly diagnosed Stage 4 diffuse anaplastic Wilms tumor (DAWT) as compared to historical controls. 1.1.2 To ...