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CSMC, IIT2021-12-Reckamp-Osi105, Ph1, open label, EGFR-mutated NSCLC, Osimertinib and Carotuximab.

Primary Objectives Determine safety and recommended phase 2 dose (RP2D) of combination osimertinib + carotuximab in patients with EGFR mutant NSCLC Secondary Objectives To evaluate the response rate (RR), duration of response (DoR), progression ...


Patient Preference for an Implantable Device to Treat Liver Ascites

The purpose of this study is to evaluate treatment system preferences of people with liver ascites. Participants will be asked questions about their experience with ascites and preferences for possible treatments via an online survey; ...


Surgery: Phantom Hindfoot TTC/TC Nail System Post-Market Clinical Follow-Up Study

This study focuses on individuals who had a surgery 12 or more months ago that included the implantation of the Phantom Hindfoot TTC/TC Nail System. The purpose of this study is to evaluate the safety ...


LungLB Lung Study

Primary: Correlate performance of LungLB Test with tissue / FNA biopsy results of an indeterminate lung nodule. Secondary: Evaluate the independent and associated contribution of readily available clinical variables including age, race, gender, socioeconomic level, environmental ...

Brain and Nervous System

COG, ACNS1422, Ph2, OL, Newly Dx WNT-Driven Medullo; Reduced Rad + Chemo

Primary Objective: 1. To estimate the progression-free survival (PFS) of children >/= 3 years of age with WNT-driven average-risk medulloblastoma using reduced craniospinal radiotherapy (CSI) (18 Gy) with a limited target volume boost to the tumor ...