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398 results found


Urinary Bladder

Bladder Preservation with Immunoradiotherapy in Muscle Invasive Bladder Cancer

This study focuses on people who have responded to chemotherapy or chemotherapy-like treatment for muscle invasive bladder cancer, and the cancer has either shrunk or cannot be found. The purpose of the study is to ...


Lymphoid Leukemia

ECOG-ACRIN, EA4231, PhII, Open, ViPOR, (DLBCL) and High-Grade B-Cell Lymphoma

Primary Objectives: A Phase II Study of Venetoclax, Ibrutinib, Prednisone, Obinutuzumab, and Revlimid (ViPOR) in Relapsed or Refractory CD10-Negative Diffuse-Large B-Cell Lymphoma (DLBCL) and High-Grade B-Cell Lymphoma with MYC and BCL2 rearrangements (HGBCL-DH-BCL2) (NCT NCT06649812) Secondary ...


Brain and Nervous System

NRG, NRG-BN013, Ph 3, Randomized, Brain Mets, SRS vs fSRS

Primary Objective: To determine if the time to local failure is improved with FSRS compared to SRS in patients with intact (i.e., unresected) brain metastases. Secondary Objectives: I. To compare time to intracranial progression-free survival between FSRS ...


Ovary

Regeneron Pharmaceuticals, Inc.R4018-ONC-2445,Ph2,Open label,rand,Ovarian CA, Ubamatamab +/- SOC Ob

Primary - Efficacy To assess the Objective Response Rate (ORR) of ubamatamab alone or in combination with bevacizumab, cemiplimab + fianlimab, or PLD (separately by study arm). Secondary: Efficacy: To assess preliminary efficacy of Ubamatamab combinations as measured by changes ...


Colon

Endevica Bio, TCMCB07-01, Ph2, Open-label, dbl-blind, Colon Cancer, TCMCB07 vs placebo

Primary Objective: To evaluate the safety of B07. Secondary Objectives: To evaluate the effect of B07 by dose level on weight, BMI, and body composition relative to placebo, over 28 days in newly diagnosed metastatic colorectal cancer patients. To ...