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391 results found


Unknown Sites

ECOG-ACRIN, EA7222, PhIII, Randomized, Doxorubicin +/- Pembrolizumab, Sarcoma

Primary Objective: To assess whether the combination of doxorubicin and pembrolizumab will improve progression free survival (PFS) in UPS and related poorly differentiated sarcomas relative to doxorubicin alone. Key Secondary Objectives: To assess whether the combination of doxorubicin ...


Pancreas

Physical Activity Using Digital Health Technology in Adults With Cachexia and Metastatic Pancreatic Ductal Adenocarcinoma

This study focuses on adults who have pancreatic cancer that has spread and caused unintentional weight loss. The purpose of the study is to evaluate whether a wearable device can be used to measure physical ...


Other

Ivonescimab Combined With Chemotherapy Versus Pembrolizumab Combined With Chemotherapy in Metastatic Non-Small Cell Lung Cancer

This study focuses on people with newly diagnosed squamous or non-squamous, non-small cell lung cancer that has spread to other areas of the body. The purpose of the study is to evaluate the effectiveness and ...


Anus, Breast, Cervix, Colon, Esophagus, Lip, Oral Cavity and Pharynx ...

Incyte, INCB177054, Ph1/2, open label, Advanced or Metastatic Solid Tumors, INCB177054

Primary -To evaluate the safety and tolerability and determine the MTD and/or RDE(s) of INCB177054 as a single agent and in combination retifanlimab. Secondary -To determine the preliminary efficacy of INCB177054 as a single agent or in combination ...


Other Digestive Organ

Revolutions Medicine, RMC-GI-102, PhI/II, GI Solid Tumors, RAS(ON)

Primary Objective: (1) Safety and tolerability of interventions on each subprotocol and (2) RP2D for interventions on each subprotocol Secondary Objectives: (1) Characterization of PK and (2) antitumor activity (ORR, DOR, DCR, TTR, and PFS per ...