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BostonScientific_PF334_OPTIMIZE

The objective of the OPTIMIZE Study is to establish the safety of PFA of pulmonary veins and EGF identified extra-PV sources (PVI + EGF ablation of sources) and to demonstrate its non-inferiority in effectiveness compared ...


Breast

Elacestrant Versus Standard Endocrine Therapy in Early Breast Cancer With High Risk of Recurrence

The purpose of this study is to compare elacestrant with standard endocrine therapy in people with node-positive, estrogen receptor-positive (ER+), HER2-negative early breast cancer who are considered to have a high risk of recurrence. Participants ...


Breast

Jazz Pharmaceuticals, Inc, JZP598-303, Ph3, rand/open, zanidatamab+SOC vs trastuzumab+SOC, Br Ca

Primary Objective: Compare the efficacy of zanidatamab plus chemotherapy versus trastuzumab plus chemotherapy Secondary Objectives: Further compare the efficacy of zanidatamab plus chemotherapy versus trastuzumab plus chemotherapy Evaluate the safety and tolerability of zanidatamab plus chemotherapy ...


Multiple Myeloma

Etentamig and Daratumumab Compared to Daratumumab, Lenalidomide, and Dexamethasone in Multiple Myeloma

The purpose of this study is to evaluate the safety of a drug called etentamig and identify the optimal dose of the drug when combined with another drug, daratumumab, in people with newly diagnosed multiple ...


Unknown Sites

Xaluritamig in Relapsed or Refractory Ewing Sarcoma

The purpose of this study is to learn more about how treatment with an experimental drug called xaluritamig works in children, adolescents and young adults with Ewing sarcoma (EWS) that has come back after treatment ...