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BL-M07D1 in Subjects With HER2 Expressing Advanced Malignant Solid Tumors

The purpose of this study is to evaluate the safety, tolerability, and effectiveness of an experimental drug called BL-M07D1 as a possible treatment for people who have a type of advanced, inoperable cancer that expresses ...

Other

Boston Scientific Corporation_S2508_SIMPLAAFY

The primary objective is to demonstrate the safety and effectiveness of two monotherapy regimens versus dual antiplatelet (DAPT) therapy following implant with the WATCHMAN FLX Pro device.

Other

IONIS_ION582-CS2

Primary -To evaluate the efficacy of ION582 in participants with Angelman syndrome (AS) receiving ION582 vs Placebo as measured through expressive communication Secondary - To evaluate the efficacy of ION582 in participants with AS receiving ION582 vs Placebo ...

Breast

BriaCell Therapeutics, BC-IMT-04, Ph 3, Rand/Open label, Breast Ca, Bria-IMT + CPI vs TPC

Primary Objective: To evaluate the effect of the Bria-IMT regimen in combination with Check Point Inhibitor (CPI) on overall survival (OS). Secondary Objectives: To evaluate the effect of the Bria-IMT regimen with CPI on progression-free survival (PFS) To evaluate ...

Lung

BioNTech, BNT324-01, Ph Ib/II, Open-label, BNT324 + BNT327, Advanced Lung Cancer

Part 1 Primary: To determine the RP2D of BNT324 in combination with BNT327 by assessing the safety and tolerability in participants with advanced lung cancer. Secondary: To evaluate the efficacy of BNT324 in combination with BNT327 according to RECIST 1.1. Part ...