Find Clinical Trials | Cedars-Sinai

401 results found

Brain and Nervous System

NRG, NRG-BN013, Ph 3, Randomized, Brain Mets, SRS vs fSRS

Primary Objective: To determine if the time to local failure is improved with FSRS compared to SRS in patients with intact (i.e., unresected) brain metastases. Secondary Objectives: I. To compare time to intracranial progression-free survival between FSRS ...

Ovary

Regeneron Pharmaceuticals, Inc.R4018-ONC-2445,Ph2,Open label,rand,Ovarian CA, Ubamatamab +/- SOC Ob

Primary - Efficacy To assess the Objective Response Rate (ORR) of ubamatamab alone or in combination with bevacizumab, cemiplimab + fianlimab, or PLD (separately by study arm). Secondary: Efficacy: To assess preliminary efficacy of Ubamatamab combinations as measured by changes ...

Colon

Optimizing Body Weight With TCMCB07 in Patients With Newly Diagnosed Metastatic Colorectal Cancer Undergoing Chemotherapy

This study focuses on people with advanced colorectal cancer. The purpose of the study is to evaluate an experimental treatment called TCMB07 (B07) that may help cancer patients gain and/or maintain their weight while they ...

Unknown Sites

Verastem Oncology, VS-7375-101, Ph 1/2, Open, KRAS G12D-Mutant solid tumors, VS-7375

Primary Objective: Part A: VS-7375 Single Agent Dose Escalation To characterize the safety, tolerability, and AE profile of escalating doses of VS-7375 as 2L+ monotherapy administered on a daily oral schedule in participants with any KRAS ...

Unknown Sites

Zanzalintinib vs Everolimus in Locally Advanced or Metastatic Neuroendocrine Tumors

The purpose of this study is to evaluate the effectiveness of an experimental drug called zanzalintinib compared to the standard-of-care treatment, everolimus, in treating people with locally advanced or metastatic neuroendocrine tumors. Zanzalintinib is a ...