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43 results found


Anus, Bones and Joints, Brain and Nervous System, Breast, Cervix ...

Molecular Analysis for Combination Therapy Choice (ComboMATCH)

The purpose of this study is to identify patients based on gene changes or mutations in their tumor for treatment using a combination of targeted therapy. The study focuses on patients who have had a ...


Other

Observational Study of Children with Hypochondroplasia

The purpose of this study is to learn more about how children with hypochondroplasia grow. Hypochondroplasia is a genetic condition that causes short stature and short limbs. Study procedures include a body check-up (measurements) and ...


Lymphoid Leukemia, Non-Hodgkin Lymphoma

AZD0486 in Adolescents and Adults With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia

The purpose of this study is to learn more about an experimental drug called AZD0486 and determine whether it will be safe, tolerable, and effective in treating B-cell acute lymphoblastic leukemia (B-ALL). AZD0486 is ...


Unknown Sites

Children's Hospital of Philadelphia, EIIT-LIFFT, Open label, PhI/II, FET-Fused Tumors, Lurbinectedin

Primary Objective: Phase 1: To determine the safety, tolerability, pharmacokinetic profile and recommended phase 2 dose (RP2D) of lurbinectedin given on a Day 1, 4 schedule every 21 days in patients with FET fusion tumors. Phase 2: ...


Other

ER004 Post-Intra-Amniotic Treatment in Males With XLHED

The purpose of this study is to evaluate the safety and effectiveness of an experimental drug called ER004 in X-linked hypohidrotic ectodermal dysplasia (XLHED) when given before birth (injected into the amniotic fluid that surrounds ...