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Giant Cell Arteritis: Efficacy and Safety of Secukinumab

The purpose of this study is to demonstrate the effectiveness and safety of an investigational drug called secukinumab administered subcutaneously (under the skin) in adult patients with newly diagnosed or relapsing giant cell arteritis (GCA). ...


Bladder cancer detection, Urology

Early Detection of Bladder Cancer

The purpose of this study is to determine whether an investigational test can assist doctors in evaluating patients at risk of developing bladder cancer with the express purpose of detecting these cancers early, when they ...


Colon

Roche, WO42758, Intrinsic, Ph 1/1b, OL, mCRC, Inavolisib + Cetuximab or Inavolisib + Bevacizumab

Inavo + Cetux Treatment Arm Primary Efficacy Objectives: To evaluate the efficacy of Inavo + Cetux in PIK3CA-mutated CRC with no detected RAS (KRAS, NRAS) or BRAFV600E mutations Secondary Efficacy Objectives: To evaluate the efficacy of Inavo + Cetux ...


Other

MITRAL II PIVOTAL TRIAL (Mitral Implantation of Transcatheter Valves)

The purpose of this study is to establish the safety and effectiveness of a device called the Edwards SAPIEN 3 and SAPIEN 3 Ultra valves with Commander delivery system in patients with severe symptomatic calcific ...


Other

The FUNCTIon Trial

The primary objective of this study is to perform a non-inferiority, randomized controlled trial to determine if pouch-related functional outcomes following ta-IPAA are not worse than after tabd-IPAA one year after surgery in UC. The ...