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387 results found


Geriatrics, Metabolism, Obesity

Single Nuclei RNA-Seq to Map Adipose Cellular Populations and Senescent Cells in Older Subjects

The purpose of this study is to evaluate whether senescent cells (cells that age and permanently stop dividing but do not die) affect the body’s ability to metabolize (process) sugars. Researchers will examine various cells ...


Mitral Valve Regurgitation

Mitral Valve Regurgitation: Transseptal Mitral Valve Replacement System - Early Feasibility Study

The purpose of this study is to determine the safety and effectiveness of an investigational device called the Innovalve TMVR system for the treatment of a leaking mitral valve (mitral valve regurgitation). Mitral valve regurgitation ...


Pulmonary hypertension

Treprostinil Palmitil Inhalation Powder in Pulmonary Arterial Hypertension

The purpose of this study is to evaluate an experimental drug called treprostinil palmitil inhalation powder (TPIP) for the treatment of pulmonary arterial hypertension (PAH). The study aims to determine the safety, tolerability, and effectiveness ...


Other

Eliminating Post-Mastectomy Pain and Opioids With Percutaneous Cryoneurolysis

This study focuses on individuals who are scheduled for a mastectomy surgery that frequently results in moderate-to-severe pain. The purpose of the study is to determine whether temporarily freezing the nerves that go to the ...


Other

Single Versus Multiple Arterial Grafts: The ROMA WOMEN Trial

The purpose of this study is to determine the effect of single versus multiple arterial revascularization (the restoration of blood flow to an organ) for female patients undergoing coronary artery bypass surgery. Currently, an artery ...