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388 results found


Amyotrophic lateral sclerosis (ALS)

Identifying Upper Motor Neuron Pathology in ALS and Other Neurodegenerative Diseases With High-Resolution MRI

The purpose of the study is to evaluate the usefulness of a new style of brain imaging for patients with amyotrophic lateral sclerosis (ALS), variants of ALS, and other neurological disorders. This type of brain ...


Other

Biomarker-Guided CNI Substitution in Kidney Transplantation

The purpose of this study is to evaluate whether a blood test can predict how a person’s immune system will respond to a transplanted kidney. Researchers also aim to determine whether a non-standard (experimental) drug ...


Lung, Rectum

HPN328 in Advanced Cancers Associated with DLL3

The purpose of this study is to test the safety and effects of an experimental drug called HPN328 alone and in combination with another drug, atezolizumab, in patients who have small cell lung cancer or ...


Breast

Shorter Anthracycline-Free Chemo Immunotherapy in Early Triple-Negative Breast Cancer

The purpose of this study is to compare the standard-of-care chemo-immunotherapy (carboplatin/paclitaxel followed by adriamycin/cyclophosphamide plus pembrolizumab, given in 6 months) treatment for early-stage, triple-negative breast cancer to a shorter non-anthracycline chemo-immunotherapy treatment (carboplatin docetaxel ...


Other

Eplontersen in Transthyretin-Mediated Amyloid Cardiomyopathy

The purpose of this study is to evaluate the safety and effectiveness of an experimental drug called eplontersen in people with transthyretin-mediated amyloid cardiomyopathy (ATTR-CM). ATTRCM is a disease caused by change in a protein ...