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Bio-Integrative, Fiber-Reinforced Kneebar for Treating Subchondral Insufficiency Fractures of the Knee

This study focuses on patients who are undergoing an arthroscopy due to subchondral insufficiency fractures of the knee (a type of stress fracture) and for whom arthroscopy using the OSSIOfiber Trimmable Fixation Nails (a type ...


Other

Phase II Study of Unresectable Hepatocellular Carcinoma and Cirrhosis

The purpose of this study is to evaluate the effects of combined immunotherapy regimens (atezolizumab with bevacizumab) in patients with inoperable liver cancer and liver disease (cirrhosis). Participants may receive atezolizumab alone (if they are ...


Obstetrics

Expanding Prenatal Cell-Free DNA Screening Across Monogenic Disorders

The goal of this study is to develop and validate (confirm) a single gene, non-invasive prenatal test (sgNIPT) for conditions such as cystic fibrosis, spinal muscular atrophy, sickle cell disease, and certain genetic blood disorders. ...


Eclampsia, Hypertension, Obstetrics, Pre-eclampsia

Comparative Effectiveness of Two Aspirin Doses for Prevention of Hypertensive Disorders of Pregnancy

The purpose of this study is to compare 2 commonly used doses of aspirin to prevent hypertensive (high blood pressure) disorders of pregnancy (HDP) in women who are pregnant and at risk of having HDP. ...


Other

AltaValve Pivotal Trial Protocol

The purpose of this study is to evaluate the safety and effectiveness of an experimental device called the AltaValve System in people with moderate-to-severe and severe mitral regurgitation. The study aims to determine whether the ...