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Aficamten Compared to Placebo in Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy

The purpose of this study is to compare the effects of an experimental drug called aficamten and placebo (inactive substance) on the exercise capacity and health status of patients with symptomatic, non-obstructive hypertrophic cardiomyopathy (nHCM). ...


Other

AZD3427 in Heart Failure and Pulmonary Hypertension Due to Left Heart Disease

The purpose of this study is to evaluate the effectiveness, safety, and tolerability of an experimental drug called AZD3427, given in addition to standard-of-care medication, in patients with heart failure and pulmonary hypertension due to ...


Other

Inhaled Nitric Oxide for ARDS-Related Pulmonary Hypertension

The purpose of this study is to determine whether giving inhaled nitric oxide to adults with acute respiratory distress syndrome (ARDS) who have developed pulmonary hypertension (elevated blood pressure in the blood vessels of the ...


Breast

Radiotherapy Optimization for Low-Risk HER2-Positive Breast Cancer

This study focuses on individuals who have low-risk HER2-positive breast cancer, which is a type of breast cancer that tests positive for the human epidermal growth factor receptor 2. The purpose of the study is ...


Colon, Rectum

Metastatic Colorectal Cancer: Evaluating Radiation, Ablation, and Surgery

This study focuses on individuals who have advanced colorectal cancer that has spread up to 4 body sites. The purpose of the study is to compare the usual treatment alone to ablative local therapy (ALT) ...