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360 results found


Non-Hodgkin's Lymphoma

IMPT-314 in Aggressive B-Cell Non-Hodgkin Lymphoma

The purpose of this study is to evaluate experimental gene-modified immune cells called IMPT-314 for the treatment of lymphomas that have either come back after treatment or have stopped responding to treatment. IMPT-314 is a ...


Other

Benfotiamine in Patients With Early Alzheimer’s Disease

The purpose of this study is to evaluate the safety and effectiveness of an experimental drug called benfotiamine as a possible treatment for Alzheimer’s disease (AD). Benfotiamine is a lab-made version of vitamin B1 (thiamine). ...


Kidney

COG, AREN1921, Ph2, Open-label, DAWT + FHWT, chemotherapy

Primary Aims 1.1.1 To evaluate whether the addition of vincristine/irinotecan to cyclophosphamide/ carboplatin/etoposide alternating with vincristine/doxorubicin/cyclophosphamide improves the event-free survival (EFS) of patients with newly diagnosed Stage 4 diffuse anaplastic Wilms tumor (DAWT) as compared to historical controls. 1.1.2 To ...


Anus, Brain and Nervous System, Breast, Cervix, Colon, Esophagus

LCB84 as a Single Agent and in Combination With Pembrolizumab in Advanced Solid Tumors

This study focuses on individuals who have metastatic cancer (cancer that has spread) that has not responded to standard treatments or for whom no effective therapy is available. The purpose of the study is to ...


Lung

Tepotinib with or Without Ramucirumab in Stage IV or Recurrent Non-Small Cell Lung Cancer

The purpose of this study is to determine whether the combination of 2 drugs, tepotinib and ramucirumab, lowers the chance of cancer growing or spreading in people with advanced non-small cell lung cancer. Researchers will ...