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425 results found


Lung

Subcutaneous Amivantamab With Lazertinib or Subcutaneous Amivantamab With Chemotherapy in EGFR-Mutated Non-Small Cell Lung Cancer

This study focuses on people with non-small cell lung cancer (NSCLC) who have a specific mutation in a gene called the epidermal growth factor receptor (EFGR) gene. The purpose of the study is to learn ...


Other

NTLA-2001 in Transthyretin Amyloidosis With Cardiomyopathy

The purpose of this study is to understand how an experimental drug called NTLA-2001 affects a heart condition called transthyretin (TTR) amyloidosis with cardiomyopathy (ATTR-CM), a condition in which the heart muscle does not pump ...


Unknown Sites

Children's Hospital of Philadelphia, EIIT-LIFFT, Open label, PhI/II, FET-Fused Tumors, Lurbinectedin

Primary Objective: Phase 1: To determine the safety, tolerability, pharmacokinetic profile and recommended phase 2 dose (RP2D) of lurbinectedin given on a Day 1, 4 schedule every 21 days in patients with FET fusion tumors. Phase 2: ...


Other

LY3884961 in Patients With Peripheral Manifestations of Gaucher Disease

The purpose of this study is to evaluate the safety and tolerability of an experimental drug called LY3884961 in people with Gaucher disease (GD). GD causes the collection of fats in some organs and bones, ...


Eye and Orbit, Liver, Melanoma

RP2 in Combination With Nivolumab Versus Ipilimumab in Combination With Nivolumab in Metastatic Uveal Melanoma

This study focuses on immune checkpoint inhibitor-naive adults with inoperable metastatic uveal melanoma (a type of aggressive eye cancer that has not been treated with immune checkpoint inhibitor therapies). The purpose of the study is ...