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325 results found


Kidney

COG, AREN1921, Ph2, Open-label, DAWT + FHWT, chemotherapy

Primary Aims 1.1.1 To evaluate whether the addition of vincristine/irinotecan to cyclophosphamide/ carboplatin/etoposide alternating with vincristine/doxorubicin/cyclophosphamide improves the event-free survival (EFS) of patients with newly diagnosed Stage 4 diffuse anaplastic Wilms tumor (DAWT) as compared to historical controls. 1.1.2 To ...


Anus, Brain and Nervous System, Breast, Cervix, Colon, Esophagus

LCB84 as a Single Agent and in Combination With Pembrolizumab in Advanced Solid Tumors

This study focuses on individuals who have metastatic cancer (cancer that has spread) that has not responded to standard treatments or for whom no effective therapy is available. The purpose of the study is to ...


Lung

Tepotinib with or Without Ramucirumab in Stage IV or Recurrent Non-Small Cell Lung Cancer

The purpose of this study is to determine whether the combination of 2 drugs, tepotinib and ramucirumab, lowers the chance of cancer growing or spreading in people with advanced non-small cell lung cancer. Researchers will ...


Other

Standard-of-Care Diversion, Diverting Ileostomy, Following Low Anterior Resection

The purpose of this study is to collect information about the ostomy procedure and use of the stoma during surgical recovery in patients undergoing colorectal surgery. Patients with colorectal cancer often require removal of the ...


Other

Intraoperative Assessment of Tissue With Time-Resolved Fluorescence Spectroscopy

The purpose of this study is to evaluate the use of a device in the detection of tumor tissue versus normal tissue at the time of surgery. The technique used by the device is called ...