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Vedolizumab Dual Targeted Therapy with Tofacitinib in Ulcerative Colitis

The purpose of this study is to determine whether combining medications for ulcerative colitis (vedolizumab with tofacitinib) is safe and improves symptoms of the disease. This treatment combination is referred to as “dual targeted therapy” ...


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Anticoagulation for Stroke Prevention in Atrial Fibrillation After Noncardiac Surgery

The purpose of this study is to determine whether long-term treatment with an approved blood thinner reduces the risk of stroke in patients who develop short-term atrial fibrillation after non-heart surgery, versus taking no blood ...


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K-808 (Pemafibrate) in Primary Biliary Cholangitis

The purpose of this study is to determine the safety and effectiveness of an experimental drug called K-808 in participants with primary biliary cholangitis (PBC). K-808 (also called K-877-ER or pemafibrate) is designed to slow ...


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Prospective Registry to Investigate Treatment Options and Their Outcomes on Post-Traumatic Long Bones Defects

This study focuses on people who have a long bone defect (LBD), which is defined as a loss of bone tissue in any long bone of the arm or leg. Reconstructive surgery is often required. ...


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Hepatocyte Transplantation Into Periduodenal Lymph Nodes in End-Stage Liver Disease

The purpose of this study is to evaluate an experimental treatment called allogeneic hepatocyte transplantation (injection of donor liver cells) as a possible treatment for end-stage liver disease (ESLD). The study aims to identify the ...