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392 results found


Brain and Nervous System

Anti-Lag-3 and Anti-PD-1 Blockade Blockade Vs. SOC in Recurrent Glioblastoma

The purpose of this study is to evaluate the experimental combination of immunotherapy drugs, relatlimab and nivolumab, in people with brain cancer. The study aims to determine whether these drugs can increase the chance that ...


Other

Expanding Prenatal Cell-Free DNA Screening Across Monogenic Disorders

The goal of this study is to develop and validate (confirm) a single gene, non-invasive prenatal test (sgNIPT) for conditions such as cystic fibrosis, spinal muscular atrophy, sickle cell disease, and certain genetic blood disorders. ...


Other

Comparative Effectiveness of Two Aspirin Doses for Prevention of Hypertensive Disorders of Pregnancy

The purpose of this study is to compare 2 commonly used doses of aspirin to prevent hypertensive (high blood pressure) disorders of pregnancy (HDP) in women who are pregnant and at risk of having HDP. ...


Other

AltaValve Pivotal Trial Protocol

The purpose of this study is to evaluate the safety and effectiveness of an experimental device called the AltaValve System in people with moderate-to-severe and severe mitral regurgitation. The study aims to determine whether the ...


Other

Levosimendan in PH-HFpEF

This study focuses on people who have pulmonary hypertension with heart failure with preserved ejection fraction (PH-HFpEF), also known as diastolic heart failure or diastolic dysfunction. This is a type of heart failure in which ...