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Patient Outcomes After Interventions for Spontaneous Intracranial Hypotension

Spontaneous intracranial hypotension (SIH) is a neurological disorder caused by a spinal cerebrospinal fluid leak (when fluid that surrounds the brain and spinal cord leaks), leading to severe headache and other neurological symptoms. The purpose ...

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Dual Targeted Therapy in Moderate to Severe Crohn's Disease

The purpose of this study is to determine whether combining approved treatments (dual therapy) for Crohn’s disease is safe and improves patient outcomes. The treatment combinations referred to as “dual targeted therapy” are vedolizumab given ...

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Vedolizumab Dual Targeted Therapy with Tofacitinib in Ulcerative Colitis

The purpose of this study is to determine whether combining medications for ulcerative colitis (vedolizumab with tofacitinib) is safe and improves symptoms of the disease. This treatment combination is referred to as “dual targeted therapy” ...

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Anticoagulation for Stroke Prevention in Atrial Fibrillation After Noncardiac Surgery

The purpose of this study is to determine whether long-term treatment with an approved blood thinner reduces the risk of stroke in patients who develop short-term atrial fibrillation after non-heart surgery, versus taking no blood ...

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K-808 (Pemafibrate) in Primary Biliary Cholangitis

The purpose of this study is to determine the safety and effectiveness of an experimental drug called K-808 in participants with primary biliary cholangitis (PBC). K-808 (also called K-877-ER or pemafibrate) is designed to slow ...