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387 results found


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Paclitaxel and Ipatasertib In PTEN/AKT-Altered Advanced Non-Breast Solid Tumors

The purpose of this study is to evaluate the effects of combining a drug called ipatasertib with the chemotherapy drug paclitaxel in people who have advanced cancer and whose cancer has a change in genes ...


Other

Bio-Integrative, Fiber-Reinforced Kneebar for Treating Subchondral Insufficiency Fractures of the Knee

This study focuses on patients who are undergoing an arthroscopy due to subchondral insufficiency fractures of the knee (a type of stress fracture) and for whom arthroscopy using the OSSIOfiber Trimmable Fixation Nails (a type ...


Other

Phase II Study of Unresectable Hepatocellular Carcinoma and Cirrhosis

The purpose of this study is to evaluate the effects of combined immunotherapy regimens (atezolizumab with bevacizumab) in patients with inoperable liver cancer and liver disease (cirrhosis). Participants may receive atezolizumab alone (if they are ...


Movement Disorders

Safety and Efficacy of AMX0035 in Progressive Supranuclear Palsy

This study focuses on people who have been diagnosed with progressive supranuclear palsy (PSP) or have a probable diagnosis of PSP. PSP is a nervous system disease that affects nerve cells in the brain and ...


Other

Expanding Prenatal Cell-Free DNA Screening Across Monogenic Disorders

The goal of this study is to develop and validate (confirm) a single gene, non-invasive prenatal test (sgNIPT) for conditions such as cystic fibrosis, spinal muscular atrophy, sickle cell disease, and certain genetic blood disorders. ...