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Mavacamten in Symptomatic Obstructive Hypertrophic Cardiomyopathy

This study focuses on people who have been diagnosed with obstructive hypertrophic cardiomyopathy (oHCM), a condition in which the heart muscle thickens and blocks blood flow from the heart. The purpose of the study is ...


Other

Long-Term Safety and Efficacy of NNC6019-0001 in Transthretin Amyloid Cardiomyopathy

The purpose of this study is to evaluate the long-term safety and effectiveness of a medicine called NNC6019-0001 in people who have heart failure due to transthyretin (TTR) amyloidosis (build-up of abnormal protein in heart ...


Other

Transvenous Tricuspid Valve Replacement With Lux Valve Plus System in Tricuspid Regurgitation

The purpose of this study is to evaluate the safety and performance of an experimental device called the LuX-Valve Plus System in people who have severe leaks or regurgitation around the tricuspid valve of their ...


Lymphoid Leukemia

AZD0486 in Adolescents and Adults With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia

The purpose of this study is to learn more about an experimental drug called AZD0486 and determine whether it will be safe, tolerable, and effective in treating B-cell acute lymphoblastic leukemia (B-ALL). AZD0486 is ...


Breast, Kidney, Lung, Multiple Myeloma, Other Digestive Organ, Ovary, Pancreas ...

QXL138AM in Locally Advanced Unresectable and/or Metastatic Solid Tumors and Multiple Myeloma

The purpose of this study is to evaluate the safety and tolerability of an experimental drug called QXL138AM in people with advanced solid tumors and multiple myeloma. There are 2 parts to this study. In ...