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Seladelpar in Primary Biliary Cholangitis and Compensated Cirrhosis

The purpose of this study is to determine whether an experimental drug called seladelpar is effective in improving outcomes for people with primary biliary cholangitis (PBC) and compensated cirrhosis. PBC is a chronic liver disease ...


Lung

Subcutaneous Amivantamab With Lazertinib or Subcutaneous Amivantamab With Chemotherapy in EGFR-Mutated Non-Small Cell Lung Cancer

This study focuses on people with non-small cell lung cancer (NSCLC) who have a specific mutation in a gene called the epidermal growth factor receptor (EFGR) gene. The purpose of the study is to learn ...


Bile duct obstruction

Biliary Stent with Anti-migration Flaps for the Palliative Treatment of Malignant Biliary Obstruction

The purpose of this study is to evaluate how an investigational device called the Hanarostent works to relieve obstructive symptoms in patients with cancer who have a blockage in their bile duct caused by cancer. ...


Other

Targeting Inflammation and Alloimmunity in Lung Transplant Recipients With Tocilizumab

This study focuses on people who are about to have a lung transplant. The purpose of the study is to determine whether a drug called tocilizumab will, when given with standard anti-rejection medicines, lead to ...


Other

NTLA-2001 in Transthyretin Amyloidosis With Cardiomyopathy

The purpose of this study is to understand how an experimental drug called NTLA-2001 affects a heart condition called transthyretin (TTR) amyloidosis with cardiomyopathy (ATTR-CM), a condition in which the heart muscle does not pump ...