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422 results found


Movement Disorders

BIIB122 in Participants With LRRK2-Associated Parkinson's Disease

The purpose of this study is to evaluate whether an experimental drug called BIIB122 is safe and tolerable in LRRK2-associated Parkinson’s disease (LRRK2-PD) patients. LRRK2-PD is a form of Parkinson’s disease caused by genetic mutation(s) ...


Non-Hodgkin Lymphoma, Other Hematopoietic

MK-2140 in Combination With R-CHP Versus R-CHOP in Diffuse Large B-Cell Lymphoma

The purpose of this study is to evaluate the safety and effectiveness of the combination of an experimental drug called zilovertamab vedotin (MK-2140) plus a series of cancer drugs (R-CHP) in treating people with diffuse ...


Lung

Lung-MAP Non-Matched Sub-Study

This study focuses on people who have advanced non-small cell lung cancer (NSCLC) and who had previous treatment using chemotherapy that contains platinum and immunotherapy. The study is part of Lung-MAP, a large research project ...


Other

Pegozafermin in Compensated Cirrhosis Due to Metabolic Dysfunction-Associated Steatohepatitis

The purpose of this study is to learn about the safety, effectiveness, and long-term outcomes of an experimental drug called pegozafermin in people with compensated cirrhosis (advanced scarring of the liver) due to metabolic dysfunction-associated ...


Melanoma, Unknown Sites

SWOG, S2101, PhII, open label, Cabozantinib + Nivolumab, Melanoma or HNSCC

Primary Objective: 1. To evaluate the feasibility of molecular characterization based on tumor mutation burden (TMB) for participant stratification, as assessed by the proportion of participants with less than or equal to a 21-day ...