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Continued Access Study of the ShortCut Device

The purpose of this study to determine whether an experimental device called the ShortCut is safe and effective in people with a risk for coronary obstruction following a repeated bioprosthetic valve implantation. Coronary obstruction is ...


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Newly Diagnosed Very Low-risk and Low-Risk Fusion Negative Rhabdomyosarcoma

This study focuses on people who have been diagnosed with rhabdomyosarcoma (RMS), a type of cancer that occurs in the soft tissues of the body and whose cancer is considered low-risk (LR-RMS). The purpose of ...


Other

Hearts Transplanted After Non-Ischemic Heart Preservation from Extended Donors

The purpose of this study is to evaluate whether non-ischemic heart preservation (NIHP) of extended criteria donor hearts using the XVIVO Heart Preservation System (XHPS) is a safe and effective way to preserve and transport ...


Other

Intra-Amniotic ER004 as a Prenatal Treatment for Males With X-linked Hypohidrotic Ectodermal Dysplasia

The purpose of this study is to assess the effectiveness and safety of intra-amniotic administrations (injection into amniotic fluid) of an experimental drug called ER004 in male fetuses with X-linked hypohidrotic ectodermal dysplasia (XLHED). XLHED ...


Other

Dual Targeted Therapy in Moderate to Severe Crohn's Disease

The purpose of this study is to determine whether combining approved treatments (dual therapy) for Crohn’s disease is safe and improves patient outcomes. The treatment combinations referred to as “dual targeted therapy” are vedolizumab given ...