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Clofazimine Inhalation Suspension in Pulmonary Nontuberculous Mycobacterial Infection

This study focuses on people who have been diagnosed with non-tuberculous mycobacteria (NTM) lung disease. The purpose of the study is to determine whether an experimental drug called clofazimine inhalation suspension can treat NTM lung ...

Bones and Joints, Breast, Cervix, Colon, Esophagus, Kidney, Liver, Lung ...

MacroGenics, Inc., CP-MGC026-01, Phase 1/1b, Open Label, Multi-Center, Solid Tumors, MGC026

Primary Objective: To characterize the safety, tolerability, dose-limiting toxicities (DLTs), and maximum tolerated dose (MTD) or maximum administered dose (MAD) (if no MTD is defined) of MGC026. Secondary Objective(s): To characterize the systemic pharmacokinetics (PK) of ...

Unknown Sites

AMG 510 With or Without Panitumumab in Advanced Solid Tumors

This study focuses on individuals who have an advanced solid tumor and whose cancer has a change in the gene called KRAS G12C. The purpose of the study is to evaluate the effects of the ...

Other Female Genital, Unknown Sites

Neratinib Alone or in Combination with Palbociclib in HER2+ Cancers and Other Solid Tumors

This study focuses on individuals who have recurrent or persistent cancer and whose cancer expresses a protein called HER2 (human growth factor receptor 2). The purpose of the study is to determine whether a combination ...

Unknown Sites

Paclitaxel and Ipatasertib In PTEN/AKT-Altered Advanced Non-Breast Solid Tumors

The purpose of this study is to evaluate the effects of combining a drug called ipatasertib with the chemotherapy drug paclitaxel in people who have advanced cancer and whose cancer has a change in genes ...