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Phase II Study of Unresectable Hepatocellular Carcinoma and Cirrhosis

The purpose of this study is to evaluate the effects of combined immunotherapy regimens (atezolizumab with bevacizumab) in patients with inoperable liver cancer and liver disease (cirrhosis). Participants may receive atezolizumab alone (if they are ...


Brain and Nervous System, Lung

BDTX-1535 in Non-Small Cell Lung Cancer

The purpose of this study is to evaluate an experimental drug called BDTX-1535 in patients with non-small cell lung cancer. BDTX-1535 is being tested to help patients with advanced solid tumors with changes in a ...


Movement Disorders

Safety and Efficacy of AMX0035 in Progressive Supranuclear Palsy

This study focuses on people who have been diagnosed with progressive supranuclear palsy (PSP) or have a probable diagnosis of PSP. PSP is a nervous system disease that affects nerve cells in the brain and ...


Other

Expanding Prenatal Cell-Free DNA Screening Across Monogenic Disorders

The goal of this study is to develop and validate (confirm) a single gene, non-invasive prenatal test (sgNIPT) for conditions such as cystic fibrosis, spinal muscular atrophy, sickle cell disease, and certain genetic blood disorders. ...


Other

Comparative Effectiveness of Two Aspirin Doses for Prevention of Hypertensive Disorders of Pregnancy

The purpose of this study is to compare 2 commonly used doses of aspirin to prevent hypertensive (high blood pressure) disorders of pregnancy (HDP) in women who are pregnant and at risk of having HDP. ...