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414 results found


Melanoma

Fianlimab, Cemiplimab, and Ipilimumab in Anti-PD-1 Refractory Melanoma

The purpose of this study is to determine whether the drug combination of fianlimab, cemiplimab, and ipilimumab is a safe and effective treatment for refractory melanoma. The study focuses on people whose melanoma has spread ...


Breast

Ivonescimab in Combination With Carboplatin + Docetaxel in Early Stage Triple Negative Breast Cancer

The purpose of this study is to evaluate the safety and effectiveness of an experimental drug called ivonescimab when combined with standard chemotherapy (carboplatin and docetaxel) before surgery for the treatment of early stage, triple-negative ...


Other

Early Internal Fixation Vs. NonOperative Care With Early Rehabilitation for Fractures of the Pelvis

The purpose of this study is to evaluate whether early surgical treatment is more effective than nonoperative care and early rehabilitation at lowering the risk of complications in patients with pelvis fractures. Both options are ...


Other

Vutrisiran in Patients With Transthyretin Amyloidosis with Cardiomyopathy

The purpose of this study is to evaluate the safety of a drug called vutrisiran (amvuttra) and determine the effects it has on people with transthyretin amyloidosis (ATTR) with cardiomyopathy (either hereditary or wild type). ...


Other

Cognitive Function in Adrenal Cortisol Insufficiency

The purpose of this study is to learn whether patients with low levels of the hormone cortisol, a condition known as adrenal cortisol insufficiency (ACI), experience changes in their cognitive function (how they think, learn, ...