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Follow-up Study of the Serranator PTA Serration Balloon Catheter

This study focuses on people who have peripheral artery disease or a dysfunctional arteriovenous fistula and will be treated as part of routine standard care with a device called the Serranator PTA Serration Balloon Catheter ...


Other

Zorevunersen (STK-001) in Patients With Dravet Syndrome

The purpose of this study is to determine whether an experimental drug called zorevunersen (STK-001) works to reduce the number of seizures for children and adolescents with Dravet syndrome. Dravet syndrome is a severe form ...


Kidney

Short-Term Intensified Pembrolizumab and Tivozanib for High-Risk Renal Cell Carcinoma

The purpose of this study is to evaluate whether the addition of a drug called tivozanib to another drug, pembrolizumab, is better than the usual approach (pembrolizumab alone) for treating advanced kidney cancer. Specifically, researchers ...


Crohn's disease [regional enteritis], IBD, Inflammatory Bowel Disease

Moving Beyond Inflammation as a Therapeutic Target for Crohn's Disease

The purpose of this study is to evaluate the effectiveness of an experimental drug called tirzepatide for the treatment of Crohn’s disease. Participants will be randomly assigned to 1 of 2 groups. Group 1 will ...


Prostate

Ifinatamab Deruxtecan Versus Docetaxel in Metastatic Castration-Resistant Prostate Cancer

The purpose of this study is to evaluate the safety and effectiveness of an experimental drug called ifinatamab deruxtecan (I-DXd) in treating people with metastatic castration-resistant prostate cancer (mCRPC), as compared to the standard-of-care treatment, ...