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Transvenous Tricuspid Valve Replacement With Lux Valve Plus System in Tricuspid Regurgitation

The purpose of this study is to evaluate the safety and performance of an experimental device called the LuX-Valve Plus System in people who have severe leaks or regurgitation around the tricuspid valve of their ...


Lymphoid Leukemia

AZD0486 in Adolescents and Adults With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia

The purpose of this study is to learn more about an experimental drug called AZD0486 and determine whether it will be safe, tolerable, and effective in treating B-cell acute lymphoblastic leukemia (B-ALL). AZD0486 is ...


Breast, Kidney, Lung, Multiple Myeloma, Other Digestive Organ, Ovary, Pancreas ...

QXL138AM in Locally Advanced Unresectable and/or Metastatic Solid Tumors and Multiple Myeloma

The purpose of this study is to evaluate the safety and tolerability of an experimental drug called QXL138AM in people with advanced solid tumors and multiple myeloma. There are 2 parts to this study. In ...


Breast

Camizestrant Versus Standard Endocrine Therapy as Adjuvant Treatment in ER+/HER2- Early Breast Cancer

The purpose of this study is to evaluate an experimental drug called camizestrant in people diagnosed with estrogen receptor-positive, human epidermal growth factor receptor 2- negative (ER+/HER2-) early-stage breast cancer who have an intermediate or ...


Other

Magnetic Resonance Imaging Study in Multiple Sclerosis

The purpose of this study is to evaluate how well various types of magnetic resonance imaging (MRI) machines and their settings can find problems in the brain. An MRI machine takes pictures of organs and ...