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Newly Diagnosed Very Low-risk and Low-Risk Fusion Negative Rhabdomyosarcoma

This study focuses on people who have been diagnosed with rhabdomyosarcoma (RMS), a type of cancer that occurs in the soft tissues of the body and whose cancer is considered low-risk (LR-RMS). The purpose of ...

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Dual Targeted Therapy in Moderate to Severe Crohn's Disease

The purpose of this study is to determine whether combining approved treatments (dual therapy) for Crohn’s disease is safe and improves patient outcomes. The treatment combinations referred to as “dual targeted therapy” are vedolizumab given ...

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Vedolizumab-4054 UC

To determine the effect of dual targeted therapy with an anti-integrin (vedolizumab [VDZ]) and a Janus kinase (JAK) inhibitor (tofacitinib [TOF]) on clinical remission.

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K-808 (Pemafibrate) in Primary Biliary Cholangitis

The purpose of this study is to determine the safety and effectiveness of an experimental drug called K-808 in participants with primary biliary cholangitis (PBC). K-808 (also called K-877-ER or pemafibrate) is designed to slow ...

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Hepatocyte Transplantation Into Periduodenal Lymph Nodes in End-Stage Liver Disease

The purpose of this study is to evaluate an experimental treatment called allogeneic hepatocyte transplantation (injection of donor liver cells) as a possible treatment for end-stage liver disease (ESLD). The study aims to identify the ...