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325 results found

Brain and Nervous System, Lung

BDTX-1535 in Non-Small Cell Lung Cancer

The purpose of this study is to evaluate an experimental drug called BDTX-1535 in patients with non-small cell lung cancer. BDTX-1535 is being tested to help patients with advanced solid tumors with changes in a ...

Movement Disorders

Amylyx_A35-009_AMX0035 and Progressive Supranuclear Palsy

To assess the impact of AMX0035 compared to placebo on disease progression rate as measured by the Progressive Supranuclear Palsy (PSP) Rating Scale (PSPRS) To assess the impact of AMX0035 compared to placebo on disease progression ...

Corpus Uteri, Ovary

NRG, EAY191-N4, Ph2, Open-label,Ovarian and Endometrial Cancers, Selumetinib vs Selumetinib+Olaparib

1.1 Primary Objective 1.1.1 Cohort 1: Compare progression free survival of combination of olaparib and selumetinib to selumetinib alone in patients with RAS mutant ovarian cancer. 1.1.2 Cohort 2: Compare progression free survival of combination of olaparib ...

Breast

Gilead, GS-US-595-6184, Ph3, open label, TNBC, Sacituzumab+Pembro vs Txt of PI's Choice

Primary Objective: To compare invasive disease-free survival (iDFS) between SG and pembrolizumab versus treatment of physician s choice (TPC) Secondary Objectives: To compare OS between the 2 arms. To compare distant disease-free survival (dDFS) as assessed by investigator between ...

Multiple Myeloma

Abbvie, M22-574, Ph3, open-label, Multiple Myeloma, ABBV-383 vs standard available therapies

Primary Objective: To evaluate the efficacy, safety, and tolerability of ABBV-383 (a BCMA x CD3 bispecific antibody) administered as monotherapy in adult subjects with RRMM who have received at least 2 prior lines of therapy, including ...