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Itepekimab in Inadequately Controlled Chronic Rhinosinusitis With Nasal Polyps

This study focuses on people who have chronic rhinosinusitis (inflammation or swelling of the tissues lining the sinuses and the nose). The study will evaluate the effectiveness, safety, and tolerability of an experimental drug called ...


Other

Follow-up Study of the Serranator PTA Serration Balloon Catheter

This study focuses on people who have peripheral artery disease or a dysfunctional arteriovenous fistula and will be treated as part of routine standard care with a device called the Serranator PTA Serration Balloon Catheter ...


Other

Zorevunersen (STK-001) in Patients With Dravet Syndrome

The purpose of this study is to determine whether an experimental drug called zorevunersen (STK-001) works to reduce the number of seizures for children and adolescents with Dravet syndrome. Dravet syndrome is a severe form ...


Kidney

Short-Term Intensified Pembrolizumab and Tivozanib for High-Risk Renal Cell Carcinoma

The purpose of this study is to evaluate whether the addition of a drug called tivozanib to another drug, pembrolizumab, is better than the usual approach (pembrolizumab alone) for treating advanced kidney cancer. Specifically, researchers ...


Other

Moving Beyond Inflammation as a Therapeutic Target for Crohn's Disease

The purpose of this study is to evaluate the effectiveness of an experimental drug called tirzepatide for the treatment of Crohn’s disease. Participants will be randomly assigned to 1 of 2 groups. Group 1 will ...