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395 results found


Melanoma

Fianlimab, Cemiplimab, and Ipilimumab in Anti-PD-1 Refractory Melanoma

The purpose of this study is to determine whether the drug combination of fianlimab, cemiplimab, and ipilimumab is a safe and effective treatment for refractory melanoma. The study focuses on people whose melanoma has spread ...


Breast

Ivonescimab in Combination With Carboplatin + Docetaxel in Early Stage Triple Negative Breast Cancer

The purpose of this study is to evaluate the safety and effectiveness of an experimental drug called ivonescimab when combined with standard chemotherapy (carboplatin and docetaxel) before surgery for the treatment of early stage, triple-negative ...


Other

Vutrisiran in Patients With Transthyretin Amyloidosis with Cardiomyopathy

The purpose of this study is to evaluate the safety of a drug called vutrisiran (amvuttra) and determine the effects it has on people with transthyretin amyloidosis (ATTR) with cardiomyopathy (either hereditary or wild type). ...


Other

SELUTION SLR Drug Eluting Balloon in De Novo Coronary Lesions in Small Vessels

The purpose of this study is to determine whether an experimental device called the SELUTION SLR drug eluting balloon is safe and whether it works as effectively as other currently available treatments for patients with ...


Other

Improving Deceased-Donor Kidney Transplant Outcomes Via a Single Intragraft Injection of C1 Esterase Inhibitor

This study focuses on people who are waiting for a deceased donor kidney transplant and, as determined at the time of transplant, are receiving a donated kidney at risk of damage from having decreased oxygen ...