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Stoke Therapeutics Study STK-001-DS-301 EMPEROR

To assess the effect of zorevunersen to reduce the frequency of major motor seizures in patients with DS. Major motor seizures are defined as the following seizure types: hemiclonic, focal with motor signs, focal to ...


Kidney

Short-Term Intensified Pembrolizumab and Tivozanib for High-Risk Renal Cell Carcinoma

The purpose of this study is to evaluate whether the addition of a drug called tivozanib to another drug, pembrolizumab, is better than the usual approach (pembrolizumab alone) for treating advanced kidney cancer. Specifically, researchers ...


Other

Moving Beyond Inflammation as a Therapeutic Target for Crohn's Disease

The purpose of this study is to evaluate the effectiveness of an experimental drug called tirzepatide for the treatment of Crohn’s disease. Participants will be randomly assigned to 1 of 2 groups. Group 1 will ...


Prostate

Ifinatamab Deruxtecan Versus Docetaxel in Metastatic Castration-Resistant Prostate Cancer

The purpose of this study is to evaluate the safety and effectiveness of an experimental drug called ifinatamab deruxtecan (I-DXd) in treating people with metastatic castration-resistant prostate cancer (mCRPC), as compared to the standard-of-care treatment, ...


Other

Proactive Costs of Care (PCOC) Study

Primary feasibility objective: 1. To evaluate the rate of intervention completion among consented participants. Secondary efficacy objectives: 2. To evaluate the change in self-efficacy from baseline to 3 months after delivery of the Proactive Costs of Care (PCOC) intervention. Secondary safety ...