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Tirzepatide for Crohn's Disease

To test the ability for tirzepatide, a GLP-1RA, to heal the intestine in patients with medically refractory Crohn's disease.


Prostate

Ifinatamab Deruxtecan Versus Docetaxel in Metastatic Castration-Resistant Prostate Cancer

The purpose of this study is to evaluate the safety and effectiveness of an experimental drug called ifinatamab deruxtecan (I-DXd) in treating people with metastatic castration-resistant prostate cancer (mCRPC), as compared to the standard-of-care treatment, ...


Anus, Breast, Lung, Other Female Genital, Ovary, Unknown Sites

Sumitomo Pharma America, Inc, SMP-3124-101, PhI/II, Open-label, SMP-3124LP, Solid tumors

Primary Objective: Dose Escalation: Determine the Recommended Phase 2 Dose (RP2D). Assess the safety and tolerability. Dose Expansion: Evaluate preliminary antitumor activity. Secondary Objectives: Dose Escalation: Establish the plasma PK profile of SMP-3124 and SMP-3124LP. Evaluate ...


Unknown Sites

SystImmune, Inc.BL-M07D1-ST-101, PhI, Open-label, Solid Tumors, BL-M07D1

Primary Objective: To assess the safety and tolerability of BL-M07D1 in metastatic or unresectable HER2-expressing tumors To determine the MTD if reached or MAD and two or more RDEs of BL-M07D1 Secondary Objectives: To characterize the ...