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NVC-001 in Patients With LMNA-Related Dilated Cardiomyopathy

This study focuses on people who have lamin A/C protein-related dilated cardiomyopathy (LMNA-related DCM), a condition in which the heart muscle becomes weak and enlarged, making it harder for the heart to pump blood and ...


Other

Early Feasibility Study of the Append System for Left Atrial Appendage (LAA) Elimination by Invagination and Ligation

This study focuses on patients with non-valvular atrial fibrillation who are at increased risk of stroke and eligible for left atrial appendage (LAA) closure. The purpose of the study is to evaluate the safety and ...


Breast

Elacestrant Versus Standard Endocrine Therapy in Early Breast Cancer With High Risk of Recurrence

The purpose of this study is to compare elacestrant with standard endocrine therapy in people with node-positive, estrogen receptor-positive (ER+), HER2-negative early breast cancer who are considered to have a high risk of recurrence. Participants ...


Breast

Zanidatamab With Chemotherapy Compared to Trastuzumab With Chemotherapy in Metastatic HER2-Positive Breast Cancer

This study focuses on people with human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer (mBC). mBC is a type of breast cancer that has spread (metastasized) to other organs in the body. The ...


Multiple Myeloma

Etentamig and Daratumumab Compared to Daratumumab, Lenalidomide, and Dexamethasone in Multiple Myeloma

The purpose of this study is to evaluate the safety of a drug called etentamig and identify the optimal dose of the drug when combined with another drug, daratumumab, in people with newly diagnosed multiple ...