Find Clinical Trials | Cedars-Sinai

161 results found

Brain and Nervous System

Silevertinib in Combination With Temozolomide in Newly Diagnosed Glioblastoma

The purpose of this study is to determine whether combining an experimental drug called silevertinib with temozolomide (a standard treatment) after surgery and radiotherapy helps treat cancer better than using temozolomide alone in people with ...

Breast

BioNTech SE, BNT327-05, Ph3, rand/dbl-blnd, TNBC, BNT327 + chemo vs BNT327 + placebo

Primary Objective: To evaluate the safety and tolerability of pumitamig in combination with chemotherapy for the safety analysis population. Handling of intercurrent events will follow a treatment policy strategy. To evaluate PRO scores of quality-of-life by ...

Unknown Sites

PEEL-224 as a Single Agent and in Combination With Vincristine and Temozolomide

This study focuses on children who have a solid tumor that has come back (relapsed) or has not responded to standard treatments (refractory). The purpose of the study is to determine whether a drug called ...

Leukemia, other, Lymphoid Leukemia

Alliance, A042302, Ph 3, randomized, CLL/SLL, Zanubrutinib + Sonrotoclax Vs Zanubrutinib alone,

Primary Objective: To compare the progression free survival (PFS) between MRD-guided post-induction treatment strategy following zanubrutinib plus sonrotoclax therapy (Regimen C: Arms 2A+2B) to continuous zanubrutinib (Regimen A: Arm 1) as control To determine the ...

Kidney

NRG, NRG-GU012, Ph 2, randomized, RCC, SOC vs SABR + SOC

Primary Objective: To determine whether the addition of stereotactic ablative radiotherapy (SABR) to the primary tumor in combination with immunotherapy improves outcomes compared to immunotherapy alone in patients with metastatic, unresected, renal cell carcinoma (RCC). The ...