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151 results found


Lung

Tepotinib with or Without Ramucirumab in Stage IV or Recurrent Non-Small Cell Lung Cancer

The purpose of this study is to determine whether the combination of 2 drugs, tepotinib and ramucirumab, lowers the chance of cancer growing or spreading in people with advanced non-small cell lung cancer. Researchers will ...


Breast

Durvalumab Plus Chemotherapy Versus Chemotherapy Alone in HR Positive / HER2 Negative Stage II-III Breast Cancer

This study focuses on individuals who have early-stage breast cancer that is hormone receptor (HR)-positive and human epidermal growth factor receptor (HER2)-negative with high risk of cancer recurrence based on MammaPrint testing (test that analyzes ...


Eye and Orbit, Melanoma

IDE196 in Combination with Crizotinib in Metastatic Uveal Melanoma

The purpose of this study is to determine whether an experimental medication, IDE196 (also called darovasertib), in combination with another drug, crizotinib, is safe and effective in people who have cancer in their eye (uveal ...


Breast

Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Breast Cancer

The purpose of this study is to determine whether the addition of chemotherapy to hormonal therapy and ovarian suppression is more effective than the usual approach of hormonal therapy and ovarian suppression alone for treatment ...


Colon, Melanoma, Other Female Genital, Rectum

Astellas,1012-CL-0101,Ph1,open,metastatic solid tumors,ASP1012

Primary -To determine the safety and tolerability of ASP1012 in participants with locally advanced or metastatic solid tumors -To determine the MTD and/or candidate RP2D ofASP1012 Secondary -To evaluate the PK and virus shedding of ASP1012 -To evaluate the ADAs ...