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167 results found


Lymphoid Leukemia, Non-Hodgkin Lymphoma

AZD0486 in Adolescents and Adults With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia

The purpose of this study is to learn more about an experimental drug called AZD0486 and determine whether it will be safe, tolerable, and effective in treating B-cell acute lymphoblastic leukemia (B-ALL). AZD0486 is ...


Breast, Kidney, Lung, Multiple Myeloma, Other Digestive Organ, Ovary, Pancreas ...

QXL138AM in Locally Advanced Unresectable and/or Metastatic Solid Tumors and Multiple Myeloma

The purpose of this study is to evaluate the safety and tolerability of an experimental drug called QXL138AM in people with advanced solid tumors and multiple myeloma. There are 2 parts to this study. In ...


Urinary Bladder

Bladder Preservation for Patients With Muscle Invasive Bladder Cancer With Variant Histology

The goal of this study is to evaluate a treatment called trimodal therapy after a course of neoadjuvant therapy (treatment given as a first step to shrink a tumor before main treatment) as a way ...


Lung

Subcutaneous Amivantamab With Lazertinib or Subcutaneous Amivantamab With Chemotherapy in EGFR-Mutated Non-Small Cell Lung Cancer

This study focuses on people with non-small cell lung cancer (NSCLC) who have a specific mutation in a gene called the epidermal growth factor receptor (EFGR) gene. The purpose of the study is to learn ...


Unknown Sites

Children's Hospital of Philadelphia, EIIT-LIFFT, Open label, PhI/II, FET-Fused Tumors, Lurbinectedin

Primary Objective: Phase 1: To determine the safety, tolerability, pharmacokinetic profile and recommended phase 2 dose (RP2D) of lurbinectedin given on a Day 1, 4 schedule every 21 days in patients with FET fusion tumors. Phase 2: ...