Find Clinical Trials | Cedars-Sinai

166 results found

Liver

SIRT with Tremelimumab and Durvalumab for Resectable Hepatocellular Carcinoma

This study focuses on people who have liver cancer (hepatocellular carcinoma-HCC) for which they will be undergoing surgical treatment. The purpose of the study is to evaluate the safety and tolerability of neoadjuvant treatment (treatment ...

Lung

Incorporating Pathologic Complete Response in Non-Small Cell Lung Cancer to Optimize Immunotherapy

The purpose of this study is to compare the usual approach of observation (closely watching a patient’s condition after surgery) to taking an immunotherapy drug, durvalumab (MEDI4736), in people with early-stage, non-small cell lung cancer ...

Kidney

Short-Term Intensified Pembrolizumab and Tivozanib for High-Risk Renal Cell Carcinoma

The purpose of this study is to evaluate whether the addition of a drug called tivozanib to another drug, pembrolizumab, is better than the usual approach (pembrolizumab alone) for treating advanced kidney cancer. Specifically, researchers ...

Prostate

Ifinatamab Deruxtecan Versus Docetaxel in Metastatic Castration-Resistant Prostate Cancer

The purpose of this study is to evaluate the safety and effectiveness of an experimental drug called ifinatamab deruxtecan (I-DXd) in treating people with metastatic castration-resistant prostate cancer (mCRPC), as compared to the standard-of-care treatment, ...

Anus, Breast, Lung, Other Female Genital, Ovary, Unknown Sites

Sumitomo Pharma America, Inc, SMP-3124-101, PhI/II, Open-label, SMP-3124LP, Solid tumors

Primary Objective: Dose Escalation: Determine the Recommended Phase 2 Dose (RP2D). Assess the safety and tolerability. Dose Expansion: Evaluate preliminary antitumor activity. Secondary Objectives: Dose Escalation: Establish the plasma PK profile of SMP-3124 and SMP-3124LP. Evaluate ...