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152 results found


Colon, Rectum

Metastatic Colorectal Cancer: Evaluating Radiation, Ablation, and Surgery

This study focuses on individuals who have advanced colorectal cancer that has spread up to 4 body sites. The purpose of the study is to compare the usual treatment alone to ablative local therapy (ALT) ...


Breast

Elacestrant in Various Combinations in Metastatic Breast Cancer

The purpose of this study is to determine whether an endocrine therapy drug approved by the U.S. Food and Drug Administration (FDA) called elacestrant is safe and effective when given in combination with one of ...


Breast, Melanoma, Multiple Myeloma, Other Skin

STX-478 as Monotherapy and in Combination With Other Antineoplastic Agents in Advanced Solid Tumors

The purpose of this study is to evaluate an experimental drug called STX 478 that is designed to specifically target mutated cancer cells (cancer cells that have a change in genetic structure) with mutations in ...


Breast, Esophagus, Larynx, Lip, Oral Cavity and Pharynx, Lung, Melanoma ...

INCA33890 in Advanced or Metastatic Solid Tumors

The purpose of this study is to determine the safest and most effective dose of an experimental drug called INCA33890 in people with selected advanced or metastatic solid tumors. INCA33890 is an immune therapy (drug ...


Ovary

TransCon IL-2 β/​γ in Locally Advanced or Metastatic Solid Tumor Malignancies

The purpose of this study is to evaluate the safety and effectiveness of an experimental drug called TransCon IL-2 beta/gamma when given in combination with chemotherapy or in combination with another experimental drug, TransCon TLR7/8 ...