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159 results found

Bladder cancer, Ovarian cancer, Uterine cancer

Acrivon Ther, ACR-368-201/GOG-3082,Ph1b/2,Open-label,Ovarian/endometrial/uroth,ACR-368+/-Gemcitabine

Primary Arm 1 Assess the anti-tumor activity of ACR-368 monotherapy in each cohort (ovarian, endometrial, urothelial) of OncoSignature Positive subjects. Arm 2 Assess the safety and tolerability of ACR-368 in combination with LDG Determine the RP2D of LDG Secondary Arm 1 Confirmation of ...

Lung

Non-Small Cell Lung Cancer: Lung-MAP Sub-Study

The purpose of this study is to determine whether a combination of drugs (capmatinib, osimertinib, and ramucirumab) is beneficial compared to another combination (capmatinib and osimertinib) for treating non-small cell lung cancer tumors that have ...

Ovary

Comparing the Non-Inferiority of Salpingectomy to Salpingo-Oophorectomy to Reduce the Risk of Ovarian Cancer

This study aims to determine whether 2 surgical procedures are no different for ovarian cancer risk reduction in individuals with BRCA1 mutations who have completed childbearing. Researchers will compare the removal of fallopian tubes to ...

Brain and Nervous System

SMO/AKT/NF2/CDK Inhibitors in Progressive Meningiomas

This study aims to determine whether tumor genetic testing would be helpful in guiding treatment for patients with a meningioma that has gotten bigger or grown back after treatment. Meningiomas are tumors that grow on ...

Multiple Myeloma

Low-Dose Palliative Radiotherapy in Bone Metastases from Multiple Myeloma

The purpose of this study is to evaluate whether pain relief can be achieved using only 1-2 radiation treatments to a painful bone lesion in patients with multiple myeloma (MM). Bone disease is common in ...