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Neoadjuvant Immunotherapy With Response-Adapted Treatment in Resectable Stage III/IV Cutaneous Squamous Cell Carcinoma

This study focuses on people who have advanced squamous cell skin cancer that can be removed with surgery. The purpose of the study is to determine whether giving an immunotherapy drug called cemiplimab before and ...

Other

Using Circulating Tumor DNA to Risk Adapt Post-Operative Therapy for HPV-Associated Oropharyngeal Cancer

The purpose of this study is to determine whether using less intense radiation therapy and chemotherapy (chemoradiation) after trans-oral robotic surgery (TORS) will be as effective in treating HPV-associated oropharyngeal cancer as standard treatment while ...

Thoracic Cancers

Real-Time Atherosclerosis Activity After Thoracic Radiotherapy Using Sodium Fluoride Positron Emission Tomography

The purpose of this study is to determine whether an imaging scan called a Sodium Fluoride Cardiac PET/MRI (18F-NaF PET/MRI) can detect early injury to heart blood vessels (coronary arteries) in patients with stage II-IV ...

Kidney

Risk-Adapted Treatment of Unilateral Favorable Histology Wilms Tumors

The purpose of this study is to improve outcomes for children with a diagnosis of favorable histology Wilms tumor (FHWT), a cancer type in which certain microscopic characteristics of tumor cells are associated with a ...

Breast

Belzutifan Plus Fulvestrant in ER-Positive, HER2-Negative Unresectable Locally Advanced or Metastatic Breast Cancer

This study focuses on people who have been diagnosed with estrogen receptor-positive (ER+)/HER2-negative breast cancer that cannot be removed surgically, has come back, or has spread to other areas of the body, and/or has grown ...