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154 results found

Other

Ivonescimab Combined With Chemotherapy Versus Pembrolizumab Combined With Chemotherapy in Metastatic Non-Small Cell Lung Cancer

This study focuses on people with newly diagnosed squamous or non-squamous, non-small cell lung cancer that has spread to other areas of the body. The purpose of the study is to evaluate the effectiveness and ...

Colon, Other Digestive Organ, Pancreas, Rectum

A Platform Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors

This study focuses on people who have either advanced colorectal cancer or advanced pancreatic cancer that is driven by a gene known as RAS. The purpose of the study is to evaluate the safety of ...

Liver

SIRT with Tremelimumab and Durvalumab for Resectable Hepatocellular Carcinoma

This study focuses on people who have liver cancer (hepatocellular carcinoma-HCC) for which they will be undergoing surgical treatment. The purpose of the study is to evaluate the safety and tolerability of neoadjuvant treatment (treatment ...

Lung

Checkpoint Blockade in Lung Cancer Patients in the Adjuvant Setting

The purpose of this study is to compare the usual treatment alone (immune-based therapy with medications like durvalumab) to the usual treatment plus an experimental medication, AZD6738 (ceralasertib), in people with lung cancer who have ...

Lung

Incorporating Pathologic Complete Response in Non-Small Cell Lung Cancer to Optimize Immunotherapy

The purpose of this study is to compare the usual approach of observation (closely watching a patient’s condition after surgery) to taking an immunotherapy drug, durvalumab (MEDI4736), in people with early-stage, non-small cell lung cancer ...