Find Clinical Trials | Cedars-Sinai

155 results found

Breast

RLY-2608 + Fulvestrant Versus Capivasertib + Fulvestrant as Treatment for HR+/HER2- Metastatic Breast Cancer

This study focuses on people who have metastatic (spread to other areas of the body) hormone receptor-positive, human epidermal growth factor 2-negative (HR+/HER2-) breast cancer that has a mutation in a gene called PIK3CA. The ...

Anus, Breast, Colon, Liver, Lung, Pancreas, Prostate, Rectum

Phase I Study of DB-1317 in Selected Advanced/Metastatic Solid Tumors

The purpose of this Phase 1 study is to assess the safety and tolerability of an experimental drug called DB-1317 in patients with an advanced/metastatic (cancer that has spread from its original site) solid tumor ...

Anus, Breast, Cervix, Colon, Esophagus, Lip, Oral Cavity and Pharynx ...

DB-1311 in Combination With BNT327 or DB1305 in Advanced/Metastatic Solid Tumors

The purpose of this study is to evaluate the safety and tolerability of 2 experimental drug combinations in people who have been diagnosed with an advanced/metastatic (cancer that has spread from where it started) solid ...

Prostate

Amgen, 20230005, Ph3, Rand, Prostate Ca, Xaluritamig vs Cabazitaxel or 2nd ARDT

Primary Objective: 1. To compare overall survival (OS) in subjects receiving xaluritamig vs investigator s choice (cabazitaxel or second androgen receptor-directed therapy [ARDT]) Secondary Objectives: 1. To compare radiographic progression-free survival (rPFS) in subjects receiving xaluritamig vs investigator s choice ...

Pancreas

Ponsegromab in Adults With Cachexia and Metastatic Pancreatic Ductal Adenocarcinoma

This study focuses on adults who have cachexia (a condition that causes significant unintentional weight loss and muscle wasting) and newly diagnosed metastatic pancreatic cancer (cancer that has spread from the pancreas to other parts ...