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162 results found

✔ Specialty: Cancer

Lung

CSMC, IIT2021-12-Reckamp-Osi105, Ph1, open label, EGFR-mutated NSCLC, Osimertinib and Carotuximab.

Primary Objectives Determine safety and recommended phase 2 dose (RP2D) of combination osimertinib + carotuximab in patients with EGFR mutant NSCLC Secondary Objectives To evaluate the response rate (RR), duration of response (DoR), progression ...


Brain and Nervous System

COG, ACNS1422, Ph2, OL, Newly Dx WNT-Driven Medullo; Reduced Rad + Chemo

Primary Objective: 1. To estimate the progression-free survival (PFS) of children >/= 3 years of age with WNT-driven average-risk medulloblastoma using reduced craniospinal radiotherapy (CSI) (18 Gy) with a limited target volume boost to the tumor ...