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Primary Biliary Cholangitis: Setanaxib in PBC and Elevated Liver Stiffness

The purpose of this study is to determine the safety and effectiveness of an experimental drug called setanaxib for the treatment of primary biliary cholangitis (PBC, formerly known as primary biliary cirrhosis). PBC is a ...


Other

Primary Biliary Cholangitis: Volixibat in the Treatment of Cholestatic Pruritus

The purpose of this study is to determine the effectiveness and safety of an investigational drug called volixibat in treating pruritus (itching) in patients with primary biliary cholangitis (PBC). It is believed that the increased ...


Other

Linerixibat in Primary Biliary Cholangitis

The purpose of this study is to further evaluate an experimental drug called linerixibat in patients with primary biliary cholangitis (PBC). Linerixibat (also referred to as GSK2330672) works in the digestive system by stopping the ...


Nonalcoholic Fatty Liver Disease (NAFLD)

Resmetirom in Nonalcoholic Fatty Liver Disease

The purpose of this study is to determine the safety and effectiveness of an investigational drug called resmetirom in people with NASH/NAFLD and compensated cirrhosis. Specifically, the study will examine how well resmetirom works for ...


Liver cirrhosis, Portal hypertension

Zibotentan and Dapagliflozin, and Dapagliflozin Monotherapy in Cirrhosis

The purpose of this study is to learn more about the effects of 2 drugs, zibotentan and dapagliflozin, in people with liver disease (cirrhosis) with features of increased pressure in portal veins (portal hypertension). The ...