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BELIEVERS

The novelty of the BELIEVERS trial lies in being the first adequately powered, randomized study to compare TAVR and SAVR with a bioprosthesis in BAV, incorporating imaging-guided stratification to optimize outcomes, incorporating robust patient-engagement approach ...


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Siegel Transcatheter Aortic Valve Replacement in Symptomatic Severe Aortic Stenosis

The purpose of this study is to evaluate the safety and effectiveness of the experimental Siegel Transcatheter Aortic Valve Replacement (TAVR) System for the treatment of adults who have symptomatic severe native calcific aortic stenosis. ...


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Coronary Intravascular Lithotripsy (IVL) Study

The purpose of this study is to evaluate the safety and effectiveness of an experimental device called the Abbott Coronary Intravascular Lithotripsy (IVL) System to widen sections of blood vessels in the heart that are ...


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Transition Regimens to KPL-387 Monotherapy from Standard Therapies in Recurrent Pericarditis

The purpose of this study is to evaluate the effectiveness of an experimental drug called KPL-387 in people who are currently taking medications for the treatment of recurrent pericarditis (RP) and whose pericarditis symptoms are ...


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Enhancing Heart Allograft Function With the OCF Heart System

The purpose of this study is to evaluate whether an organ care system (OCS) solution with an added OCS functional enhancer (OFE) and new gas mixture can preserve donor hearts more safely and effectively than ...