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Multicenter Post-Approval Study of Congenital Pulmonic Valve Dysfunction Studying the Edwards SAPIEN 3...

The purpose of this study is to evaluate the safety and effectiveness of the Edwards SAPIEN 3 Transcatheter Pulmonary Valve System with the Alterra Adaptive Prestent, which is approved by ...


Other

A PHASE 3, MULTI-CENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL TO EVALUATE THE EFFICACY AND...

Primary Objective: To evaluate the effect of CK-3773274 on exercise capacity in patients with symptomatic oHCM. Secondary Objectives: 1. To evaluate the effect of CK-3773274 on patient health status 2. ...


Other

Efficacy and safety of NNC6019-0001 at two dose levels in participants with transthyretin...

The purpose of this study is to determine whether an investigational drug called NNC6019-0001 can be used to treat people with transthyretin (TTR) amyloid cardiomyopathy, a heart disease due to ...


Other

Expanded Access Protocol to Provide Patisiran to Patients with Transthyretin-mediated Amyloidosis (ATTR Amyloidosis)...

The objective of the study is to assess the long-term safety of patisiran in patients with ATTR amyloidosis with cardiomyopathy as assessed by a review of adverse events (AEs).


Other

Safety and Effectiveness of Balloon-Expanding Bioprosthetic Sapien X4 Trascather Heart Valve -ALLIANCE Study

The study will use the study device (Sapien X4) in patients with severe Aortic Stenosis; it study the device's safety and effectiveness