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KPL-387 Treatment in Participants With Recurrent Pericarditis

The purpose of this study is to determine whether KPL-387 is an effective and safe treatment in patients with recurrent pericarditis. Pericarditis is a condition in which the thin layers of tissue that surrounds the ...


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Modification of Coronary Calcium With Laser-Based Intravascular Lithotripsy for Coronary Artery Disease

This study focuses on people whose arteries around the heart have significant narrowing or blockage and whose doctor has recommended treatment with percutaneous coronary intervention (PCI) and lithotripsy procedure. The purpose of the study is ...


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Focused Orticumab Research for Treating Inflammation in Coronary Arteries

The purpose of this study is to determine the safety and effectiveness of an experimental drug called orticumab for the treatment of coronary inflammation in people with prior myocardial infarction (heart attack) who have elevated ...


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Ninerafaxstat in Patients With Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy (FORTITUDE-HCM)

The purpose of this study is to evaluate the effects and safety of an experimental drug called ninerafaxstat in people who are experiencing symptoms from non-obstructive hypertrophic cardiomyopathy (nHCM, also called “symptomatic nHCM”). In nHCM, ...


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VDyne_TPR0037-P_VISTA EFS

This is a feasibility study using the IDE device VDyne Transcatheter Tricuspid Valve in patients with severe tricuspid regurgitation. The purpose of this early feasibility study (EFS) is to evaluate the safety and clinical performance ...