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Coronary Intravascular Lithotripsy (IVL) Study

The purpose of this study is to evaluate the safety and effectiveness of an experimental device called the Abbott Coronary Intravascular Lithotripsy (IVL) System to widen sections of blood vessels in the heart that are ...


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OCEAN(a)-CCTA

1. To evaluate the effect of olpasiran, compared to placebo, on non-calcified plaque (NCP) volume as measured by Coronary Computed Tomography Angiography (CCTA) 2. To evaluate the effect of olpasiran, compared to placebo, on changes in different ...


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Transition Regimens to KPL-387 Monotherapy from Standard Therapies in Recurrent Pericarditis

The purpose of this study is to evaluate the effectiveness of an experimental drug called KPL-387 in people who are currently taking medications for the treatment of recurrent pericarditis (RP) and whose pericarditis symptoms are ...


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Enhancing Heart Allograft Function With the OCF Heart System

The purpose of this study is to evaluate whether an organ care system (OCS) solution with an added OCS functional enhancer (OFE) and new gas mixture can preserve donor hearts more safely and effectively than ...


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LBBAP Versus CRT-D in Heart Failure, “SYNCHRONICITY”

This study focuses on people who have been diagnosed with heart failure and whose doctor has recommended that they receive an implant of a cardiac resynchronization therapy defibrillator (CRT-D), a type of medical device. The ...