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85 results found


ATTR-CM, Cardiac amyloidosis

AG10-304

The purpose of this study is to evaluate the safety and effectiveness of an investigational drug called acoramidis (AG10) for the treatment of a rare disease called symptomatic transthyretin amyloid cardiomyopathy (ATTR-CM). ATTR-CM occurs when ...


Other

Cephea Early Feasibility Study

The purpose of this study is to evaluate an investigational device called the Cephea Mitral Valve System, which is designed for the treatment of a diseased, damaged, or malfunctioning mitral valve. Specifically, the study aims ...


Pulmonary hypertension

Pulmonary Arterial Hypertension: Treprostinil Palmitil Inhalation Powder in Pulmonary Arterial Hypertension (INS1009)

The purpose of this study is to evaluate an investigational drug called treprostinil palmitil inhalation powder (TPIP) for the treatment of pulmonary arterial hypertension (PAH). The study aims to determine the effectiveness and tolerability of ...


Other

MITRAL II PIVOTAL TRIAL (Mitral Implantation of Transcatheter Valves)

The purpose of this study is to establish the safety and effectiveness of a device called the Edwards SAPIEN 3 and SAPIEN 3 Ultra valves with Commander delivery system in patients with severe symptomatic calcific ...


Heart Transplant, Heart failure

Heart Transplant, Heart Failure: Evaluating the Safety of Utilizing Donor Hearts from Donation after Circulatory Death (DCD) Donors compared to Donor Hearts from Donation after Brain Death (DBD) Donors (DCD IIT)

The purpose of this study is to evaluate the safety of using hearts from donors after circulatory death (DCD) compared to hearts from donors after brain death (DBD) in individuals who have been listed to ...