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71 results found


Heart failure

Implantable CCM in the Heart Failure Group With Higher Ejection Fraction

The purpose of this study is to determine whether cardiac contractility modulation (CCM), a heart failure device therapy that improves contraction of the heart, will reduce cardiovascular mortality and heart failure hospitalizations in certain patients. ...


Other

Percutaneous Intervention Versus Observational Trial of Arterial Ductus in Low Weight Infants

This study compares 2 methods of treating infants who were born prematurely with a patent ductus arteriosus (PDA). A PDA is a blood vessel connecting the lungs and the heart. All infants have a PDA ...


Other

Coronary Sinus Reducer in Refractory Angina II (COSIRA-II)

The purpose of this study is to collect information on the safety and effectiveness of an investigational device called the Reducer for treatment of patients with refractory (persistent) angina. Angina is a type of chest ...


Mitral Valve Regurgitation

Mitral Valve Regurgitation: Transseptal Mitral Valve Replacement System - Early Feasibility Study

The purpose of this study is to determine the safety and effectiveness of an investigational device called the Innovalve TMVR system for the treatment of a leaking mitral valve (mitral valve regurgitation). Mitral valve regurgitation ...


Pulmonary hypertension

Treprostinil Palmitil Inhalation Powder in Pulmonary Arterial Hypertension

The purpose of this study is to evaluate an experimental drug called treprostinil palmitil inhalation powder (TPIP) for the treatment of pulmonary arterial hypertension (PAH). The study aims to determine the safety, tolerability, and effectiveness ...