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MITRAL II PIVOTAL TRIAL (Mitral Implantation of Transcatheter Valves)

The purpose of this study is to establish the safety and effectiveness of a device called the Edwards SAPIEN 3 and SAPIEN 3 Ultra valves with Commander delivery system in patients with severe symptomatic calcific ...


Heart Transplant, Heart failure

Heart Transplant, Heart Failure: Evaluating the Safety of Utilizing Donor Hearts from Donation after Circulatory Death (DCD) Donors compared to Donor Hearts from Donation after Brain Death (DBD) Donors (DCD IIT)

The purpose of this study is to evaluate the safety of using hearts from donors after circulatory death (DCD) compared to hearts from donors after brain death (DBD) in individuals who have been listed to ...


Other

Edwards SAPIEN 3 Transcatheter Pulmonary Valve System with Alterra Adaptive Prestent

The purpose of this study is to evaluate the safety and effectiveness of the Edwards SAPIEN 3 Transcatheter Pulmonary Valve System with the Alterra Adaptive Prestent, which is approved by the U.S. Food and Drug ...


Cardiomyopathy

Efficacy and Safety of CK3773274 in Symptomatic Hypertrophic Cardiomyopathy and Left Ventricular Outflow Tract Obstruction

This study focuses on individuals who have obstructive hypertrophic cardiomyopathy (oHCM, a condition in which the heart muscle is abnormally thick) and who also have left ventricular outflow tract (LVOT) obstruction, a condition that interferes ...


ATTR-CM, Cardiac Amyloidosis

ATTR CM: Efficacy and Safety of NNC6019-0001 in Transthyretin Amyloid Cardiomyopathy (ATTR CM)

The purpose of this study is to determine whether an investigational drug called NNC6019-0001 can be used to treat people with transthyretin (TTR) amyloid cardiomyopathy, a heart disease due to TTR amyloidosis. Participants will undergo ...