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51 results found

ATTR-CM, Cardiac Amyloidosis

ATTR CM: Efficacy and Safety of NNC6019-0001 in Transthyretin Amyloid Cardiomyopathy (ATTR CM)

The purpose of this study is to determine whether an investigational drug called NNC6019-0001 can be used to treat people with transthyretin (TTR) amyloid cardiomyopathy, a heart disease due to TTR amyloidosis. Participants will undergo ...

ATTR-CM, Cardiac Amyloidosis

ATTR Amyloidosis With Cardiomyopathy: Expanded Access Protocol to Provide Patisiran

This study is an Expanded Access Program that focuses on individuals who have transthyretin amyloidosis with cardiomyopathy (ATTR amyloidosis with cardiomyopathy). Expanded Access Programs are a means by which investigational treatments are made available to ...


Aortic Stenosis: Balloon-Expandable Bioprosthetic SAPIEN X4 Transcatheter Heart Valve

The purpose of this study is to determine whether an investigational device called the Sapien X4 Transcatheter Heart Valve system is beneficial for patients with symptomatic, severe, calcific aortic stenosis. Aortic stenosis is a condition ...

Pulmonary hypertension

Pulmonary Hypertension: Sotatercept versus Placebo (CADENCE)

This study focuses on individuals who have been diagnosed with a form of pulmonary hypertension (PH) associated with left heart disease, known as heart failure with preserved ejection fraction (HFpEF). PH is a disease affecting ...

Familial hypercholesterolemia

Bempedoic Acid in Pediatric Patients With Heterozygous Familial Hypercholesterolemia

The purpose of this study is to evaluate the investigational use of a drug called bempedoic acid in individuals who have heterozygous familial hypercholesterolemia (HeFH). HeFH is a condition in which there are higher-than-normal amounts ...