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MYK-224 in Symptomatic Hypertrophic Cardiomyopathy and Left Ventricular Outflow Tract Obstruction

The purpose of this study is to examine the safety and effectiveness of an investigational drug called MYK-224 in individuals with obstructive hypertrophic cardiomyopathy (oHCM). The amount of MYK-224 that reaches the blood stream and ...


Other

Coronary Sinus Reducer in Refractory Angina II (COSIRA-II)

The purpose of this study is to collect information on the safety and effectiveness of an investigational device called the Reducer for treatment of patients with refractory (persistent) angina. Angina is a type of chest ...


Other

Aficamten Compared to Metoprolol in Symptomatic Obstructive Hypertophic Cardiomyopathy

The purpose of this study is to compare the effectiveness and potential side effects of an investigational drug called aficamten with the beta-blocker, metoprolol, in people with obstructive hypertrophic cardiomyopathy (oHCM). Obstructive HCM is a ...


Mitral Valve Regurgitation

Mitral Valve Regurgitation: Transseptal Mitral Valve Replacement System - Early Feasibility Study

The purpose of this study is to determine the safety and effectiveness of an investigational device called the Innovalve TMVR system for the treatment of a leaking mitral valve (mitral valve regurgitation). Mitral valve regurgitation ...


Pulmonary hypertension

Treprostinil Palmitil Inhalation Powder in Pulmonary Arterial Hypertension

The purpose of this study is to evaluate an experimental drug called treprostinil palmitil inhalation powder (TPIP) for the treatment of pulmonary arterial hypertension (PAH). The study aims to determine the safety, tolerability, and effectiveness ...