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Coronary Sinus Reducer in Refractory Angina II (COSIRA-II)

The purpose of this study is to collect information on the safety and effectiveness of an investigational device called the Reducer for treatment of patients with refractory (persistent) angina. Angina is a type of chest ...


Mitral Valve Regurgitation

Mitral Valve Regurgitation: Transseptal Mitral Valve Replacement System - Early Feasibility Study

The purpose of this study is to determine the safety and effectiveness of an investigational device called the Innovalve TMVR system for the treatment of a leaking mitral valve (mitral valve regurgitation). Mitral valve regurgitation ...


Pulmonary hypertension

Treprostinil Palmitil Inhalation Powder in Pulmonary Arterial Hypertension

The purpose of this study is to evaluate an experimental drug called treprostinil palmitil inhalation powder (TPIP) for the treatment of pulmonary arterial hypertension (PAH). The study aims to determine the safety, tolerability, and effectiveness ...


Other

Thoraflex Hybrid and Relay Extension Post-Approval Study

The purpose of this study is to gather further information on the standard-of-care use of a device called the Thoraflex Hybrid alone and in combination with the RelayPro NBS Stent-Graft to treat aortic disease. The ...


Other

Eplontersen in Transthyretin-Mediated Amyloid Cardiomyopathy

The purpose of this study is to evaluate the safety and effectiveness of an experimental drug called eplontersen in people with transthyretin-mediated amyloid cardiomyopathy (ATTR-CM). ATTRCM is a disease caused by change in a protein ...