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Thoraflex Hybrid and Relay Extension Post-Approval Study

The purpose of this study is to gather further information on the standard-of-care use of a device called the Thoraflex Hybrid alone and in combination with the RelayPro NBS Stent-Graft to treat aortic disease. The ...


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Eplontersen in Transthyretin-Mediated Amyloid Cardiomyopathy

The purpose of this study is to evaluate the safety and effectiveness of an experimental drug called eplontersen in people with transthyretin-mediated amyloid cardiomyopathy (ATTR-CM). ATTRCM is a disease caused by change in a protein ...


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Aficamten Compared to Placebo in Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy

The purpose of this study is to compare the effects of an experimental drug called aficamten and placebo (inactive substance) on the exercise capacity and health status of patients with symptomatic, non-obstructive hypertrophic cardiomyopathy (nHCM). ...


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AZD3427 in Heart Failure and Pulmonary Hypertension Due to Left Heart Disease

The purpose of this study is to evaluate the effectiveness, safety, and tolerability of an experimental drug called AZD3427, given in addition to standard-of-care medication, in patients with heart failure and pulmonary hypertension due to ...


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SELUTION SLR 014 Drug Eluting Balloon in the Treatment of In-Stent Restenosis

The purpose of this study is to demonstrate whether an investigational device called the SELUTION SLR drug eluting balloon is well tolerated and whether it works as effectively as other currently available treatments for patients ...