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152 results found


Breast

Adjuvant Sacituzumab Govitecan and Pembrolizumab in Triple-Negative Breast Cancer

The purpose of this study is to evaluate an experimental drug called sacituzumab govitecan in combination with pembrolizumab, or pembrolizumab with or without capecitabine, in people with high-risk, early triple-negative breast cancer without mutations (changes) ...


Lymphoid Leukemia

AZD0486 in Adolescents and Adults With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia

The purpose of this study is to learn more about an experimental drug called AZD0486 and determine whether it will be safe, tolerable, and effective in treating B-cell acute lymphoblastic leukemia (B-ALL). AZD0486 is ...


Urinary Bladder

Bladder Preservation for Patients With Muscle Invasive Bladder Cancer With Variant Histology

The goal of this study is to evaluate a treatment called trimodal therapy after a course of neoadjuvant therapy (treatment given as a first step to shrink a tumor before main treatment) as a way ...


Brain and Nervous System

Glioblastoma Accelerated Biomarkers Learning Environment Trial

The purpose of this study is to identify new biological markers (specific biological features) associated with scans of a brain tumor that will help doctors predict how tumors might develop and affect the health of ...


Other Digestive Organ

AZD0901 Monotherapy Compared With Investigator’s Choice of Therapy in Advanced/Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma

The purpose of this study is to evaluate the effectiveness and safety of an experimental drug called AZD0901 compared to a standard therapy selected by the participant’s study doctor (per their disease status) and to ...