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Phase II Study of Unresectable Hepatocellular Carcinoma and Cirrhosis

The purpose of this study is to evaluate the effects of combined immunotherapy regimens (atezolizumab with bevacizumab) in patients with inoperable liver cancer and liver disease (cirrhosis). Participants may receive atezolizumab alone (if they are ...


Brain and Nervous System, Lung

BDTX-1535 in Non-Small Cell Lung Cancer

The purpose of this study is to evaluate an experimental drug called BDTX-1535 in patients with non-small cell lung cancer. BDTX-1535 is being tested to help patients with advanced solid tumors with changes in a ...


Corpus Uteri, Ovary

Selumetinib and Olaparib or Selumetinib Alone in Ovarian and Endometrial Cancers

This study focuses on people who have recurrent or persistent ovarian or endometrial cancer and whose cancer has a change in the gene family called RAS genes. The purpose of the study is to compare ...


Breast

Adjuvant Sacituzumab Govitecan and Pembrolizumab in Triple-Negative Breast Cancer

The purpose of this study is to evaluate an experimental drug called sacituzumab govitecan in combination with pembrolizumab, or pembrolizumab with or without capecitabine, in people with high-risk, early triple-negative breast cancer without mutations (changes) ...


Pancreas

RMC-6236 Versus Standard-of-Care Therapy in Previously Treated Metastatic Pancreatic Ductal Adenocarcinoma

The purpose of this study is to evaluate an experimental drug called RMC-6236 in pancreatic cancer patients whose cancer has spread outside the pancreas (metastatic) and whose cancer has returned after treatment or did not ...