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133 results found


Lymphoid Leukemia

AZD0486 in Adolescents and Adults With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia

The purpose of this study is to learn more about an experimental drug called AZD0486 and determine whether it will be safe, tolerable, and effective in treating B-cell acute lymphoblastic leukemia (B-ALL). AZD0486 is ...


Breast

Camizestrant Versus Standard Endocrine Therapy as Adjuvant Treatment in ER+/HER2- Early Breast Cancer

The purpose of this study is to evaluate an experimental drug called camizestrant in people diagnosed with estrogen receptor-positive, human epidermal growth factor receptor 2- negative (ER+/HER2-) early-stage breast cancer who have an intermediate or ...


Urinary Bladder

Bladder Preservation for Patients With Muscle Invasive Bladder Cancer With Variant Histology

The goal of this study is to evaluate a treatment called trimodal therapy after a course of neoadjuvant therapy (treatment given as a first step to shrink a tumor before main treatment) as a way ...


Brain and Nervous System, Melanoma, Other Hematopoietic, Soft Tissue

Cobolimab in Combination with Dostarlimab in Pediatric and Young Adult Participants With Newly Diagnosed and Relapsed/Refractory Tumors

The purpose of this study is to evaluate an experimental drug called cobolimab, given with dostarlimab (an anti-cancer medication used in adults) in children, teens, and young adults whose cancer has spread to other parts ...


Brain and Nervous System

Glioblastoma Accelerated Biomarkers Learning Environment Trial

The purpose of this study is to identify new biological markers (specific biological features) associated with scans of a brain tumor that will help doctors predict how tumors might develop and affect the health of ...