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148 results found


Prostate

CSMC, IIT2023-10-Posadas-PC-NET, open-label, pilot, Prostate Ca, epigenetic therapy + prostatectomy

Primary Objective: 1. To assess the safety, toxicity, and feasibility of using epigenetic therapy in the perioperative setting for men undergoing radical prostatectomy (RP). 2. To assess the feasibility of measuring changes in gene expression (in radical ...


Breast

Pfizer, C4391024, Ph3, Open-label, randomized, Br CA, PF-07220060+Letrozole vs CDK4/6+ Letrozole

Primary Objective: To compare the efficacy of PF07220060 in combination with letrozole (Arm A) versus CDK4/6i (investigator s choice: abemaciclib, palbociclib, or ribociclib) in combination with letrozole (Arm B) with respect to progression-free survival (PFS). Secondary Objectives: To ...


Other Female Genital

Gilead/GOG, GS-US-682-6769/GOG-3104, Ph 3, open,Sacituzumab Govitecan vs TPC,Endometrial CA

Primary: To compare the effect of sacituzumab govitecan (SG) relative to treatment of physician s choice (TPC) on progression-free survival (PFS) as assessed by blinded independent central review (BICR) To compare the effect of SG relative to ...