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155 results found


Prostate

Xaluritamig vs Cabazitaxel or Second Androgen Receptor-Directed Therapy in Metastatic Prostate Cancer

The purpose of this study is to determine the safety and effectiveness of an experimental drug called xaluritamig when compared to standard treatments in people with prostate cancer that has spread to other parts of ...


Pancreas

Ponsegromab in Adults With Cachexia and Metastatic Pancreatic Ductal Adenocarcinoma

This study focuses on adults who have cachexia (a condition that causes significant unintentional weight loss and muscle wasting) and newly diagnosed metastatic pancreatic cancer (cancer that has spread from the pancreas to other parts ...


Leukemia, not otherwise specified

Ziftomenib in Combination With Nonintensive or Intensive Therapy in Acute Myeloid Leukemia

This study focuses on people with acute myeloid leukemia (AML) and consists of 2 independent studies/ treatment regimens. AML is a type of blood cancer in which infection-fighting cells (white blood cells) do not mature ...


Breast

Shortened Duration of Adjuvant Therapy in Early-Stage HER2+ Breast Cancer

This study focuses on people who have been diagnosed with HER2-positive (HER2+) breast cancer and have recently completed chemotherapy in combination with a drug called trastuzumab, followed by breast surgery. The chemotherapy plus trastuzumab produced ...


Colon

CSMC, IIT2022-11-Gangi-SAMe, Ph2, Open-label, S-Adenosylmethionine (SAMe), Colorectal Cancer.

Primary Objective 1 To identify the effect of SAMe in preventing oxaliplatin associated liver injury as determined by lack of injury on histopathologic analysis in patients with liver predominant stage IV colorectal cancer. Secondary Objectives 1 To estimate the Objective ...