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155 results found


Anus, Colon, Lung, Pancreas, Rectum

BBO-11818 in Advanced KRAS Mutant Cancers

This study focuses on people who have advanced non-small cell lung cancer, colorectal cancer, pancreatic ductal adenocarcinoma, or other solid tumor with a specific KRAS mutation (change in the KRAS gene that plays a part ...


Prostate

Mevrometostat With Enzalutamide in Metastatic Castration-Sensitive Prostate Cancer

This study focuses on people who have metastatic castration-sensitive prostate cancer (mCSPC) and have not received treatment with novel hormonal therapy or chemotherapy in the mCSPC setting. The purpose of the study is to learn ...


Colon, Lung, Melanoma, Rectum

mRNA-4359 Alone and in Combination With Immune Checkpoint Blockade

This study focuses on people who have locally advanced, metastatic, or relapsed solid tumor cancer (cancer that can be measured and has worsened and become larger and/or spread to other parts of the body). The ...


Prostate

SWOG, S1802, Ph III, Randomized, Prostate Ca, SST vs SST + surgery or radiation

Primary Objective: To compare overall survival in metastatic prostate cancer patients who are randomized to standard systemic therapy (SST) plus definitive treatment of the primary tumor versus standard systemic therapy alone. Secondary Objectives: I. To compare overall survival ...


Small Intestine, Stomach

DRX-42 Versus Sunitinib in Metastatic and/or Unresectable Gastrointestinal Stromal Tumors After Imatinib Therapy

The purpose of this study is to determine the safety and effectiveness of an experimental drug called IDRX-42 compared to a drug called sunitinib (standard-of-care treatment) in people who have been diagnosed with advanced gastrointestinal ...