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135 results found


Breast

Camizestrant Versus Standard Endocrine Therapy as Adjuvant Treatment in ER+/HER2- Early Breast Cancer

The purpose of this study is to evaluate an experimental drug called camizestrant in people diagnosed with estrogen receptor-positive, human epidermal growth factor receptor 2- negative (ER+/HER2-) early-stage breast cancer who have an intermediate or ...


Urinary Bladder

Bladder Preservation for Patients With Muscle Invasive Bladder Cancer With Variant Histology

The goal of this study is to evaluate a treatment called trimodal therapy after a course of neoadjuvant therapy (treatment given as a first step to shrink a tumor before main treatment) as a way ...


Brain and Nervous System, Melanoma, Other Hematopoietic, Soft Tissue

Cobolimab in Combination with Dostarlimab in Pediatric and Young Adult Participants With Newly Diagnosed and Relapsed/Refractory Tumors

The purpose of this study is to evaluate an experimental drug called cobolimab, given with dostarlimab (an anti-cancer medication used in adults) in children, teens, and young adults whose cancer has spread to other parts ...


Brain and Nervous System

Glioblastoma Accelerated Biomarkers Learning Environment Trial

The purpose of this study is to identify new biological markers (specific biological features) associated with scans of a brain tumor that will help doctors predict how tumors might develop and affect the health of ...


Other Digestive Organ

AZD0901 Monotherapy Compared With Investigator’s Choice of Therapy in Advanced/Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma

The purpose of this study is to evaluate the effectiveness and safety of an experimental drug called AZD0901 compared to a standard therapy selected by the participant’s study doctor (per their disease status) and to ...