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15 results found

Lymphoid Leukemia

Genmab, GCT3013-03, Ph 1/2b, Open-Label, GEN3013, Leukemia/Richter's Syndrome

Objectives and Endpoints: Dose Escalation Monotherapy Cohorts (R/R CLL): Primary Objective: Identify the RP2D and the MTD of epcoritamab Evaluate the safety and tolerability of epcoritamab Secondary: Characterize the PK properties of epcoritamab Evaluate immunogenicity of epcoritamab Assess the preliminary antitumor activity ...

Myeloid and Monocytic Leukemia

MYELOMATCH, Master Screening and Reassessment Protocol

In this study, researchers will plan various treatment substudies for people with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) who have not yet started treatment. Participants will be asked to undergo testing on their ...

Leukemia, other

COG, AALL1821, Ph 3, rando, open-label, relapsed B-ALL, Blinatumomab +/- Nivolumab

Primary: 1. To compare rate of minimal residual disease (MRD) negative second remission (Rem-2, see definition in Section 3.3.3) after up to two cycles of Reinduction with blinatumomab vs. blinatumomab/nivolumab in Group 1 patients aged ? ...

Lymphoid Leukemia

Cytarabine Plus Daunorubicin Compared to Experimental Groups in High-Risk Acute Myeloid Leukemia

This study focuses on individuals who have been recently diagnosed with high-risk, acute myeloid leukemia (AML) and have not yet started treatment. Researchers want to know whether they can shrink the amount of AML or ...

Lymphoid Leukemia

Comparing Rituximab and Mosunetuzumab in Low Tumor Burden Follicular Lymphoma

The purpose of this study is to compare the usual treatment (rituximab) to an experimental drug called mosunetuzumab in people with low tumor burden follicular lymphoma. Mosunetuzumab is a type of drug known as a ...