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6 results found


Breast, Colon, Esophagus, Kidney, Other Digestive Organ, Other Female Genital ...

Identifying Cryptic Causes for High-Risk Hereditary Cancer Syndromes

Hereditary cancer syndromes are caused by germline mutations or epimutations (an epigenetic error that switches a gene off) within cancer-related genes. These mutations or epimutations confer a high risk of cancer development in individuals and ...


Other Endocrine System, Pancreas

Merck, MK-6482-015, Ph 2, Open-label, PPGL & pNET, MK6482 Monotherapy

The purpose of this study is to evaluate the investigational use of a drug called belzutifan (MK-6482) in people with certain types of pheochromocytoma/ paraganglioma (PPGL) and pancreatic neuroendocrine tumors (pNET). The study will examine ...


Other Digestive Organ

Capecitabine and Temozolomide Versus Observation in Pancreatic Neuroendocrine Tumors

This study focuses on people who have had surgery for pancreatic neuroendocrine tumor (pNET), a type of cancer that forms tumors in the pancreas. The purpose of the study is to determine whether giving chemotherapy ...


Unknown Sites

Nivolumab and Relatlimab in Advanced Mismatch Repair Deficient Cancers

The purpose of this study is to evaluate how the combination of the drugs nivolumab and relatlimab might work in people with advanced cancer that is “microsatellite instability high” (MSI-H). Microsatellite instability is a marker ...


Cervix, Kidney, Lung, Other Female Genital, Pancreas, Rectum, Small Intestine

KO-2806 in Adult Patients With Advanced Solid Tumors

The purpose of this study is to determine the highest tolerable dose of an investigational drug called KO-2806 in combination with an approved therapy called cabozantinib, in people with renal cell carcinoma (RCC) of predominantly ...