Anticoagulation for Stroke Prevention in Atrial Fibrillation After Noncardiac Surgery

What is the Purpose of this Study?

The purpose of this study is to determine whether long-term treatment with an approved blood thinner reduces the risk of stroke in patients who develop short-term atrial fibrillation after non-heart surgery, versus taking no blood thinner. Participants will be randomly assigned to either the “no oral anti-coagulant group” or the “non-vitamin K oral anticoagulation (blood thinner) group.” Patients who are assigned to the non-vitamin K oral anticoagulant group will receive either rivaroxaban or apixaban, as determined by their physician. These anticoagulants are approved by the U.S. Food and Drug Administration (FDA) for use in people with nonvalvular atrial fibrillation to reduce the risk of stroke and blood clots. It is currently unclear whether the drugs are also effective and safe in patients with short-term atrial fibrillation after surgery. Researchers will collect information about how often stroke, bleeding, and other blood vessel-related complications occur in patients who take these medications. The results of the study may be used to help create guidance for the use of blood thinners.


Eligibility

  • 1. noncardiac surgery in the past 35 days with at least one of the following:
  • 1. an overnight hospital admission after surgery;
  • 2. day surgery resulting in a large enough physiological insult to be able to cause perioperative AF, as judged by the local investigator
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Where can I participate?

Beverly

More about this Clinical Trial

What is the full name of this clinical trial?

Anticoagulation for Stroke Prevention In patients with Recent Episodes of perioperative Atrial Fibrillation after noncardiac surgery - The ASPIRE-AF trial

Study Details
Disease Type/Condition

Other

Principal Investigator

Braunstein, Eric

Age Group

Adult

Phase

IV

IRB Number

STUDY00003399

ClinicalTrials.gov ID

NCT03968393

Key Eligibility
ClinicalTrials.gov

How do I learn more about this study?
Email
clinicaltrials@cshs.org
Study Detail
Disease Type/Condition

Other

Principal Investigator

Braunstein, Eric

Age Group

Adult

Phase

IV

IRB Number

2019-ASPIREAF

ClinicalTrials.gov ID

NCT03968393

Key Eligibility
ClinicalTrials.gov

Contact
Email
clinicaltrials@cshs.org