Primary objective: To compare the complete remission (CR) rates by FDG PET/CT using the Lugano 2014 criteria following completion of treatment with duvelisib-CHO(E)P vs CHO(E)P and with CC-486-CHO(E)P vs CHO(E)P in previously untreated peripheral T-cell lymphomas that have <10% expression of CD30. Secondary objective(s) 2.2.1 To determine the toxicity and tolerability of the treatment regimens. 2.2.2 To determine the complete remission (CR) rates by FDG PET/CT or CT alone using the Lugano 2014 criteria. 2.2.3 To determine the overall response rate (ORR), duration of response, progression free survival (PFS), event free survival (EFS), and overall survival (OS) of each treatment regimen. 2.2.4 To determine whether designation of follicular helper T-cell phenotype is correlated with response to therapy, PFS, EFS, and OS. 2.2.5 To assess the toxicity profile of the experimental regimens in untreated CD30 negative peripheral T-cell lymphomas using CTCAE and PRO-CTCAE.
What is the full name of this clinical trial?
A051902: A randomized phase II study of CHOP vs CC-486- CHOP vs duvelisib-CHOP in previously untreated CD30 negative peripheral T-cell lymphomas *