Open vs. Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

Summary

The purpose of this study is to compare the effects of 2 surgery methods for people with bone cancer (osteosarcoma- OST) that has spread to the lung. The 2 types of surgeries are called open thoracic surgery and thoracoscopy. Open thoracic surgery is a type of surgery performed through a single larger incision that goes between the ribs, opens up the chest, and removes the cancer (referred to as “open surgery.”) Thoracoscopy is a type of chest surgery in which several small incisions are made and uses a small camera to help with removing the cancer (“video-assisted thoracoscopic surgery” or VATS). Participants will be randomly assigned to receive open surgery or VATS. The study aims to provide evidence to inform the optimal thoracic surgical management of these patients.


Inclusion Criteria

  • Patients must be < 50 years at the time of enrollment.
  • Patients must have =< 4 nodules per lung consistent with or suspicious for metastases, with at least one of which being >= 3 mm and all of which must be =< 3 cm size.
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Study Location(s)

Cedars-Sinai Cancer at SOCC : Amy Oppenheim

More about this Clinical Trial

Full Title

AOST2031: A Phase 3 Randomized Controlled Trial Comparing Open vs Thoracoscopic Management of Pulmonary Metastases in Patients with Osteosarcoma ^

Details
Disease Type/Condition

Lung

Principal Investigator

Majlessipour, Fataneh

Co-Investigators

Behrooz Hakimian, Nicole Baca

Age Group

Both

Phase

III

IRB Number

STUDY00002751

ClinicalTrials.gov ID

NCT05235165

Key Eligibility
ClinicalTrials.gov

Contact
Name

Amy Oppenheim

Phone
+1 310-423-3713
Email
amy.oppenheim@cshs.org
Want to join the study or
learn more?

Details
Disease Type/Condition

Lung

Principal Investigator

Majlessipour, Fataneh

Age Group

Both

Phase

III

IRB Number

AOST2031

ClinicalTrials.gov ID

NCT05235165

Key Eligibility
ClinicalTrials.gov

Contact
Name

Amy Oppenheim

Phone
+1 310-423-3713
Email
amy.oppenheim@cshs.org
Want to join the study or
learn more?