Anticoagulation in Intracerebral Hemorrhage Survivors for Stroke Prevention and Recovery

What is the Purpose of this Study?

The purpose of this study is to compare the effects of a drug called apixaban to aspirin in patients with atrial fibrillation (irregular heart rate) and a recent brain hemorrhage to determine which is more effective for the prevention of future strokes. Participants will be randomly assigned to 1 of 2 groups. Group 1 will receive aspirin 81 milligrams once per day, plus a placebo (inactive) pill twice per day. Group 2 will receive apixaban 5 milligrams twice per day, plus a placebo pill once per day. Apixaban is approved by the U.S. Food and Drug Administration (FDA) for stroke prevention in patients with atrial fibrillation, but its use in this study is experimental.


Eligibility

  • * Age at least 18 years
  • * Intracerebral hemorrhage (ICH) (including primary intraventricular hemorrhage) confirmed by brain CT or MRI
  • * Can be randomized within 14-180 days after ICH onset
  • * Non-valvular AF (defined as atrial fibrillation or atrial flutter), documented by electrocardiography or a physician-confirmed history of prior AF
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Where can I participate?

Beverly

More about this Clinical Trial

What is the full name of this clinical trial?

Anticoagulation in Intracerebral Hemorrhage Survivors for Stroke Prevention and Recovery

Study Details
Disease Type/Condition

Stroke

Principal Investigator

Schlick, Konrad

Co-Investigators

Shlee Song

Age Group

Adult

Phase

III

IRB Number

STUDY00000354

ClinicalTrials.gov ID

NCT03907046

Key Eligibility
ClinicalTrials.gov

How do I learn more about this study?
Email
clinicaltrials@cshs.org
Study Detail
Disease Type/Condition

Stroke

Principal Investigator

Schlick, Konrad

Age Group

Adult

Phase

III

IRB Number

ASPIRE

ClinicalTrials.gov ID

NCT03907046

Key Eligibility
ClinicalTrials.gov

Contact
Email
clinicaltrials@cshs.org