Elranatamab in Combination With Other Anti-Cancer Treatments in Multiple Myeloma

What is the Purpose of this Study?

The purpose of the study is to learn whether an investigational drug called nirogacestat can improve the effectiveness of another drug, elranatamab, in treating patients with multiple myeloma who have had their disease relapse. Elranatamab is comprised of two antibodies (sometimes called a 'bispecific antibody'). Elranatamab binds to T cells (a type of immune system cell) and myeloma cells. This process hopefully causes the T cells to recognize and kill the myeloma cells. Elranatamab is administered as a shot under the skin. Nirogacestat is a type of drug known as a gamma secretase inhibitor and is designed to reduce the shedding of the protein (BCMA) that elranatamab binds to. By potentially keeping more of this BCMA protein on the myeloma cell, it is hoped that the efficacy of elranatamab will be increased. Nirogacestat is taken as a pill.


Eligibility

  • * Relapsed/refractory multiple myeloma with at least 3 prior lines of therapy
  • * Refractory to at least one IMiD, one proteasome inhibitor, and one anti-CD38 antibody
  • * Measurable disease defined by at least one of the following:
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Where can I participate?

CS Cancer at Cedars-Sinai Medical Center

More about this Clinical Trial

What is the full name of this clinical trial?

C1071004: Magnetismm-4, A Phase 1B/2, Open Label Umbrella Study of Elranatamab , A B-Cell Maturation Antigen CD3 Bispecific Antibody, In Combination With Other Anti-Cancer Treatments in Participants With Multiple Myeloma

Study Details
Disease Type/Condition

Multiple Myeloma

Principal Investigator

Vescio, Robert

Co-Investigators

David Oveisi, Joshua Sasine, Justin Darrah, Noah Merin, Ronald Paquette

Age Group

Adult

Phase

I/II

IRB Number

STUDY00002085

ClinicalTrials.gov ID

NCT05090566

Key Eligibility
ClinicalTrials.gov

How do I learn more about this study?
Email
clinicaltrials@cshs.org
Study Detail
Disease Type/Condition

Multiple Myeloma

Principal Investigator

Vescio, Robert

Age Group

Adult

Phase

I/II

IRB Number

C1071004

ClinicalTrials.gov ID

NCT05090566

Key Eligibility
ClinicalTrials.gov

Contact
Email
clinicaltrials@cshs.org