Left Bundle Branch Area Pacing Versus Conventional Cardiac Resynchronization Therapy in Heart Failure

What is the Purpose of this Study?

This study focuses on people who have been diagnosed with heart failure (a condition in which the heart muscle is unable to pump enough blood to the body), have left bundle branch block (LBBB, a condition in which the electrical impulse traveling to the left ventricle is delayed or fully blocked), and whose doctor has recommended that they receive an implant of a cardiac resynchronization therapy defibrillator (CRT-D). A CRT-D device is designed to monitor and treat heart rhythm problems (arrhythmias). The study will compare 2 ways to pace the heart to treat heart failure: cardiac resynchronization therapy (CRT) and Left Bundle Branch Area Pacing (LBBAP). CRT is the standard approach of implanting a pacing lead (LV lead) in a vein on the surface of the left ventricle of the heart to deliver heart failure therapy. The other way (LBBAP) uses a lead (INGEVITY+TM pace/sense lead) implanted in the left bundle branch area (LBBA) of the heart. This lead is approved by the U.S. Food and Drug Administration (FDA), but its use in this study is considered experimental. Participants will be randomly assigned to 1 of 2 groups. Participants in the CRT group will receive the same device system and lead implant locations as they would have if they did not participate in the study. Those in the LBBAP group will receive the same CRT-D device system as they would have if they did not participate in this study, as well as the LBBAP lead (INGEVITY+) implanted in the LBBA location.

Eligibility

1. Patient is age 18 years or above, or of legal age to give informed consent specific to state and national law
2. Patient meets a guideline-based indication for a de novo CRT-D device
3. Primary prevention indication for ICD therapy
4. Ischemic or nonischemic cardiomyopathy with LVEF ≤ 35% within 6 months of enrollment (LVEF must be assessed after the subject has been on GDMT for a minimum of 3 months) using an appropriate method of assessment (i.e. Echo, MRI, etc)

Inclusion Criteria:

1. Patient is age 18 years or above, or of legal age to give informed consent specific to state and national law
2. Patient meets a guideline-based indication for a de novo CRT-D device
3. Primary prevention indication for ICD therapy
4. Ischemic or nonischemic cardiomyopathy with LVEF ≤ 35% within 6 months of enrollment (LVEF must be assessed after the subject has been on GDMT for a minimum of 3 months) using an appropriate method of assessment (i.e. Echo, MRI, etc)
5. NYHA class II-IV despite maximally tolerated guideline directed medical therapy (GDMT)\* for at least 3 months
\*GDMT is defined as all four drug classes listed below for at least 3 months prior to enrollment unless the investigator provides justification (e.g., contraindicated, not tolerated or cost): Renin Angiotensin System Inhibitors (ACE, ARB, or ARNI) Evidence based betablockers (metoprolol succinate, carvedilol, bisoprolol) Mineralocorticoid antagonists SGLT2 Inhibitor medications
6. Sinus rhythm with left bundle branch block (LBBB) defined as a QRS ≥ 140 ms in men and ≥ 130 ms in women with a predominantly negative deflection (QS or rS in lead V1 and mid QRS notching or slurring in at least two of the following leads: 1, aVL, V1, V2, V5, V6) within 3 months of enrollment
7. Patient is willing to participate in LATITUDE™ NXT remote patient monitoring
8. Patient is willing and capable of providing informed consent and participating in all testing associated with this investigation at an approved study site and at the protocol defined intervals (Note: Use of a legally authorized representative (LAR) is not allowed)
9. Patient plans to remain geographically stable (not permanently moving to another location) and can commit to all study participation requirements (procedure, follow-up visits and testing requirements)

Exclusion Criteria:

1. Persistent or permanent atrial fibrillation (AF) within 3 months prior to enrollment and documented in the medical record
2. Frequent premature ventricular contractions (PVCs), atrial arrhythmias, and/or other causes of expected percentage of cardiac physiologic pacing (CPP) delivery below 95% at the time of enrollment
3. Non-LBBB conduction abnormalities (including right bundle branch block (RBB) or intraventricular conduction delay (IVCD)) within 3 months prior to enrollment
4. Complete, second degree or high degree atrioventricular (AV) block, that requires pacing at the time of enrollment
5. Current or prior pacemaker, ICD or CRT implant (Also includes non-transvenous ICD technology and leadless pacemakers)
6. Prior or planned mechanical or bioprosthetic tricuspid valve replacement
7. Currently receiving or previously received positive inotrope therapy within 3 months prior to enrollment
8. Unstable angina, acute myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention within 3 months prior to enrollment
9. History of heart transplantation or left ventricular assist device (LVAD) implantation
10. Less than 1 year of life expectancy at the time of enrollment
11. Anticipated heart transplantation or LVAD implantation within 1 year of enrollment
12. History of ventricular septal defect (VSD)
13. Complex congenital heart disease
14. Documented diagnosis of cardiac amyloidosis
15. Known occlusion or other reason limiting central venous access for transvenous leads
16. Women of childbearing potential who are, or plan to become, pregnant during the course of the study (assessment per investigator's discretion)
17. Patient currently requiring dialysis
18. Patient with known or suspected sensitivity to Dexamethasone Acetate (DXA)
19. Patient with contrast dye allergy or unwilling/able to undergo pre-treatment with steroids and/or diphenhydramine
20. Inability or refusal to comply with the follow-up schedule including subject living at such a distance from the investigational site that attending follow-up visits would be unusually difficult or burdensome
21. Patient is enrolled in any other concurrent study. Co-enrollment into other studies such as observational studies/registries needs prior written approval by BSC. Local mandatory governmental registries are accepted for co-enrollment without approval by BSC.

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Where can I participate?

Beverly

More about this Clinical Trial

What is the full name of this clinical trial?

Safety and Effectiveness of Left Bundle Branch Area Pacing versus Conventional Cardiac Resynchronization Therapy in Heart Failure

Study Details

Disease Type/Condition

Other

Principal Investigator

Tang, Stephen

Co-Investigators

Saarik Gupta, Sarina Van Der Zee, Stephen Tang

Age Group

Adult

Phase

N/A

IRB Number

STUDY00004516

ClinicalTrials.gov ID

NCT07069738

Key Eligibility

ClinicalTrials.gov

How do I learn more about this study?

Email

clinicaltrials@cshs.org